Cathy receives two minor pieces of bad news on her latest check up. The first is that none of the drugs' listed negative side effects have afflicted her, which to her means that the drugs aren't working. The second is that she has high blood pressure. Despite Cathy disregarding it upon Sean's suggestion, Cathy takes Lee's advice to visit an acupuncturist - his acupuncturist - to treat the high blood pressure. The acupuncturist has slightly better news: she immediately relaxed, which means a drop in blood pressure, when Lee entered the room. The acupuncturist attributes that relaxation to her and Lee being soul mates, which to Cathy can only mean in the spiritual but non-sexual sense seeing as to Lee's homosexual orientation. But those homo/heterosexual boundaries between Lee, Cathy and Paul are tested, as are Cathy's notions of what it means truly to be one's soul mate. Meanwhile, Mykail is anticipating his first date with Andrea and what he hopes will happen.

As Cathy (Laura Linney) treats a skeptical Paul (Oliver Platt) to a cancer survivor's personal growth seminar, a Valentine's Day concert causes Adam (Gabriel Basso) to rethink his relationship with his girlfriend.

Series finale. Adam fulfills one of Cathy's wishes.