John Bennett, a man whose childhood wish of bringing his teddy bear to life came true, now must decide between keeping the relationship with the bear, Ted or his girlfriend, Lori.
Using a crack team of doctors and his wits, an antisocial maverick doctor specializing in diagnostic medicine does whatever it takes to solve puzzling cases that come his way.
When a psychopath commits murders based on novelist Castle's books, Detective Beckett seeks his help to solve the case. He decides to work with her and uses his experiences as research for his novels.