Dr. Mike and the reverend are skeptical when a so-called religious healer comes to town.

Dr. Mike and Sully are traveling through obnoxious Native American territory when their stagecoach is robbed and they are abandoned. With them are a just married Kid Cole and Sister Ruth as they try and reach home for Thanksgiving. Evading hostile tribesmen is only the beginning.

Dr. Mike sees that the marriage of Kid Cole and Sister Ruth is unraveling and the couple is heading for divorce for no apparent reason. Johnny Cash and June Carter Cash reprise their roles as Kid Cole and Sister Ruth. When Cole and his wife stop to see Dr. Mike while escorting mail-order brides to San Francisco, Dr. Mike immediately feels the tension in the air between them. She then learns that Cole is terminally ill and, in an attempt to spare Ruth the agony of watching him die, has created problems in their relationship so Ruth won't feel obligated to care for him. Ruth, meanwhile, is devastated at her husband's behavior and talk of divorce and seeks Dr. Mike's advice.