Vincent Chase is a young, hot, up-and-coming actor living in Hollywood. Tonight, he must attend the opening of his latest movie "Head On," but first he and his three best friends from back home (Queens, NY) have lunch and discuss their upcoming 10-year high school reunion. Vince is reluctant to go but his buddies urge him to go with them. At the post-premiere party, Vince's agent, Ari, hassles Eric about getting Vince to read the script for a possible new project. Over breakfast, Vince says he's not going to do "Matterhorn" on Eric's advice. The foursome goes to meet with the director where Vince impresses him so much that Ari calls later to tell him that they've offered $4 million for the part. While Turtle and Drama celebrate, Vince lets him know that Eric is not too enthused about the script. Later, Ari and Eric share a rather confrontational dinner while discussing the future of their star's career. After Vince decides to take Eric's advice not to do the movie, the boys leave for their reunion. Before they can drive off, though, they get a call with some bad news: Colin Farrell has taken the part.

Eric tries to make a deal for 2 new clients. Drama does whatever it takes to keep his relationship with Jacqueline. An old flame returns to Vince.

Vince and Drama take on Tom Brady and Mark Wahlberg at a charity golf event. E gets an unexpected job offer. Ari is in trouble with Mrs. Ari.

Vince's behavior worries his new director. Billy Walsh's newest pitch for a show rankles Drama but intrigues Eric. Ari must negotiate with Lizzie Grant to retrieve incriminating evidence.