Vincent Chase is a young, hot, up-and-coming actor living in Hollywood. Tonight, he must attend the opening of his latest movie "Head On," but first he and his three best friends from back home (Queens, NY) have lunch and discuss their upcoming 10-year high school reunion. Vince is reluctant to go but his buddies urge him to go with them. At the post-premiere party, Vince's agent, Ari, hassles Eric about getting Vince to read the script for a possible new project. Over breakfast, Vince says he's not going to do "Matterhorn" on Eric's advice. The foursome goes to meet with the director where Vince impresses him so much that Ari calls later to tell him that they've offered $4 million for the part. While Turtle and Drama celebrate, Vince lets him know that Eric is not too enthused about the script. Later, Ari and Eric share a rather confrontational dinner while discussing the future of their star's career. After Vince decides to take Eric's advice not to do the movie, the boys leave for their reunion. Before they can drive off, though, they get a call with some bad news: Colin Farrell has taken the part.

While Drama practices for his acting class over breakfast, Turtle enters with some bad news: an important trade magazine has given Vince's performance a negative review (including calling him a "fly-by-night pretty boy"). While paying Ari an office visit to discuss it, Eric meets Ari's new assistant, Emily. Following Ari's advice to show Vince a good time to get his mind off the review, Eric okays Vince's poor decision to lease a new Rolls Royce. Jessica Alba bumps into the boys during their luncheon and invites them to her party for Justine Chapin, her virginal pop-singer friend. The party proves to be a good time for everybody: Justine hits on Vince, Turtle shows off the Rolls to some girls, Eric gets some much needed assurance, and Drama finds that he isn't the only one skipping his acting class. In the morning, Eric reads Vince a review from the New York Times proclaiming him to be "the next Johnny Depp."