A bomb in a brief case goes off in the lobby of an office building. The team must piece together all the parts of this bomb to look for the maker's signature. Nick becomes involved in a crime after spending a night with a woman who ends up dead the next day.

A human bone is found in the desert accidentally by a dog playing fetch with a man and his son. Grissom and Catherine assemble a team to comb the area for more bones. Back at the lab, they piece together the skeleton and determine that body was cut to pieces. From his teeth, the deceased is identified as a 70-year-old Mel Bennett. Catherine and Grissom pay a visit to his wife, who claims that her husband is at a nearby store. Sara and Warrick are called to a motel where a male stripper is found dead on the bed. The room is registered to a woman who recently threw a bachelorette party for her friend.

A Jane Doe is brutally attacked and raped before being left to die on the side of the road. With two bullets lodged in her brain, she is in a deep coma. Catherine and Warrick work on an open case of a man killed by his neighbor. The statements from the accused and the deceased's wife contradict each other.

When a young woman riding a horse finds a body of a woman inside a pipe in a construction site, Grissom and his team investigate the murder. Soon they find another woman's body and coroner Dr. Albert 'Al' Robbins notes that the women are very different despite being sisters. Their further investigation indicate the Donna Marks was a reclusive woman, maybe agoraphobic, while Joan Marks had a different behavior. Meanwhile, Catherine and Nick investigate the murder of the hunter James Jasper in the woods. James was an insurance broker and an experienced hunter, but was not wearing the safety vest. Catherine, Nick and Detective Vega learn that Jasper and his wife Linda had lost their jobs. When they find a one-million dollar life insurance on behalf of Linda, his wife becomes their prime suspect.

A taxi driver accidentally runs over a teenage boy. He is later brutally beaten by a gang who thinks he is running away. Grissom and Sara works on the case and finds that the boy was dead prior to being hit from a stab wound.

Matt Phelps sends his two kids to bed, and out of the blue, there is a drive-by shooting and his daughter Aimee is shot and killed in her bed. Grissom, Warrick and Capt. Brass investigate the case and Grissom learns that Matt Phelps is Warrick's mentor and friend. Warrick's investigation is conducted based on his emotions instead of on the evidences with serious consequences for Matt and a suspect. Meanwhile, Nick and Sam Vega investigate the mysterious death of a boss of a four-men Internet service company in the air-conditioned servers' room. They find many secrets in the team but no suspect and no murder weapon. Until Nick observes the duct of the air-conditioning.

Because Warrick naively assumed simple uniformed cop Hal Watson would have arranged a search warrant, the crucial weapon in the rape and murder trial on a neighbor against Michael Fife is dismissed as evidence in court. A.D.A. Jeffrey Sinclair can only get a 24 hours delay to present new evidence to build the case again. Nick brilliantly smooths emotional waywardness from Sarah and Warrick. New clues expected to reconstruct the case against Fife actually indicate he's probably innocent. An alternative culprit must be found, starting from Fife's car where the bloody knife was planted.

When a roller coaster derails in an amusement park, there are six victims in the parking lot. Grissom, Nick, Sara and Capt. Brass investigate the case and soon they find that five deceased persons were in the train, but the employee Jim Nevins died twenty-hours before with a head trauma. Grissom interviews the park chief engineer Woody and learns that the old roller coaster has good maintenance. Grissom shows a nut to Woody and he says that it would be impossible to cause the train derail since there are eight sets that would have to lose. Meanwhile, Catherine and Warrick investigate the murder of the thirteen-year-old Tessa Press that was found murdered but not raped. Her mother Raina tells them that Tessa used to go to the house of a friend twice a week and she had assumed that her daughter was with her friend. Now they need to find what has happened to her.

While giving his testimony in a retrial, Grissom sees fingerprints on a matchbox that he does not recall. The victim Max Larson was found dead I his hardware store hit by a wrench. He requests a recess to the DA and reopens the investigation of the case. He follows the protocol and assigns Catherine, Warrick and Nick to investigate the case again and why they have missed the fingerprint in their investigation. Ecklie asks Sofia to investigate Grissom's cases and begins a witch hunt in the laboratory. Meanwhile, Sara, Greg and Det. Louis Vartann investigate the case of a John Doe, who died after shooting his own leg. When they succeed to find the register of the gun, they find clue of another case.

Grissom, Sofia and Greg investigate a gang shooting with two victims. Out of the blue, Greg finds the body of a young boy dumped in a trash bin. Sara and David Phillips join the investigation. Dr. Robbins notes in the autopsy that the boy was around five years old, was abused with several recent fractures and died of starvation. A further investigation identifies the boy as Devon Malton and Sara and Capt. Brass visit the foster home where he lived with Lorna Tenney. Meanwhile, Catherine, Nick, Warrick and Det. Louis Vartann investigate the case of the prisoner Samuel Mendez that was beaten up in a riot in a cell and now is brain dead. Warrick sees a gun in the cell that was under Samuels body. Lt. Arthur Chen that is the responsible for the prisoners has an argument with Warrick when he comments about a sloppy police search and abuse of force. Soon they learn that Samuel Mendez is not the wanted criminal but an innocent namesake.

When the young mother Lori Kyman is reported missing by her husband, Grissom and Sofia meets with Capt. Brass on the highway where her car was found with flat tire. Sara and Capt. Brass go to Lori's house to interview her husband Mark, and they find her best friend Amy Maynard. Lori's stepmother Diane Hoyt arrives and confirms Mark's alibi. Soon Greg finds that the valve of the flat tire in Lori's car was unscrewed leaking the air, and he finds prints. Meanwhile, Catherine, Warrick and Nick investigate the deaths of the hunter Rod Hollis with claws around his neck and a Kodiak bear in the woods. However, the animal is not native from the area. In the autopsy, Dr. Robbins finds that bear was shot twice, by Hollis' rifle and by a Magnum .357 that was used in a robbery and belongs to Aaron Colite. A microchip in the bear shows that he belonged to Clark County Zoo and was bought by a broker.

The CSI's investigate the death of a very hairy man. At a quick glance, the body can be easily mistaken for a werewolf. The man died from a gun shot wound. He, along with his sister, has a rare genetic disorder which causes excessive hair growth.

A pedophile arsonist maintains his innocence in the disappearance of two young boys, but he is also willing to help the investigation by giving Grissom insight on the potential kidnapper's mindset.

WLVU's head football coach is murdered, and the case is connected to a wealthy booster, a dead prostitute, and the team's star running back.