As the "Heroes" continue to test their newfound extraordinary abilities, Claire tries to maintain a normal social life when a romance with the football quarterback takes a tragic turn. While Hiro convinces his friend that they are destined to travel to America to save the world, a frightened Niki follows instructions from a mysterious, unknown source that directs her to the middle of the desert. Meanwhile, Nathan uses Peter's accident to propel his political campaign. The elusive Sylar is being hunted by both Matt and the FBI, as well as Suresh, whose father's journal leads to potential clues.

Suresh finally tracks down one of his father's fabled genetically advanced "supermen." In Las Vegas, Hiro's plan backfires when he cautiously turns time to his advantage at the gambling tables. Niki's mafia debtors use their leverage to their benefit in a more elaborate scheme, while Nathan pays a personal visit to a wealthy Vegas contributor to raise additional campaign funds. Following a tragic turn at a bonfire, Claire's uncanny healing abilities are put to the ultimate test, but according to Isaac's paintings, her future could be fraught with even more peril. Meanwhile, Matt's abilities are gauged by a pair of men who seem to know a great deal about people with special gifts.

Niki is questioned by police about her fugitive husband's whereabouts; Matt's relationship with his wife, Janice, benefits from his mind-reading abilities; Claire divulges her secret to her father; Hiro has a violent run-in with Las Vegas high rollers; Peter receives a life-changing message; and Mohinder contemplates leaving New York---and his father's research---behind.

With the election and NYC's destruction looming, Nathan has a disturbing face-to-face meeting with the shadowy Linderman. Hiro's attempt to steal the sword steers him into a grim new direction. Suresh makes a breakthrough on "the list" -- at great cost. D.L. begins to suspect all is not well at home. Isaac paints his most terrible painting yet. New "hero" Candice Wilmer makes an illusive debut.