Nathan, whose special power is immortality, has been buried alive but he is rescued after a mysterious masked and hooded figure sends Kelly a paper dart reading 'Go To His Grave'. Shaun, a new probation officer, laid back to the point of boredom, arrives and takes the group to help at an art therapy class for the emotionally disturbed where Simon meets Lucy, with whom he was once in a psychiatric unit. She is a shape-shifter, who morphs into each group member to tell them that Simon killed Sally, hoping he will be put back in the unit with her. However, since she loves him, she keeps his secret, though it is now common knowledge to the other misfits, who dump the corpse in the river, watched by the masked man.

Nathan is approached by the tattooed, denim-clad Jamie, who claims to be his half-brother, conceived out of wedlock. He has recently found out and, to punish their no-good father Mike, has him tied up in the boot of his car. After the boys retrieve the car which gets stolen and rescue their dad, Jamie and the misfits go to a club where pill-popping seems to reverse their powers and Curtis has a vision of a girl falling from a high roof. The mysterious hoodie reappears and Simon trails him to a flat block but when he and the others break in they find the girl who featured in Curtis's vision. Jamie has sex in a car with a girl whose super power is to turn things to ice but as a result of the reversal she causes herself and Jamie to combust. Nathan learns that his brother is dead. He can, however, still see him as if he were alive due to the change in his power.

The masked man saves Alisha from a mugging on the estate. It appears he is able to touch her without being affected by her powers.

Ollie, an environmental protester who has the power to teleport, starts his community service. But is he really destined to become part of the gang?

Having walked in on charity worker Jessica getting changed, Nathan finds that the lights have gone out and he has been 'killed' again. He and the other misfits are certain that the murderer is Jessica and attempt to warn Simon,who has become her boyfriend. Simon,however,is not convinced,despite the fact that another boy has been killed and his body disappeared. After Simon and Jessica have had sex he is subjected to a murderous attack but saved by Alisha. Curtis and Nikki also get it together whilst Kelly has a strange encounter with Bruno,who is not what he seems. However the gang of five and Nikki decide to celebrate their survival by having a drink on the roof of the centre.

Brian, another youngster hit by the storm, develops the power to control dairy products, and, to impress a would-be girlfriend, goes public with his special ability, being known as Milkman. This leads the misfits - despite reluctance from Simon - to also go public and, with a manager Laura to promote them, they become famous as the Asbo Five. Pushed onto the side-lines Milkman becomes murderously resentful and takes to killing innocent by-standers as well as setting a trap to put paid to his celebrity rivals. Curtis will have to bring his special powers into play to save his friends and return things to normal.

Whilst Kelly has trouble convincing people of her new power, the skills of a rocket scientist and Curtis finds his new gift, the ability to change sex useful when pursued by the police, the group learns that Nathan has gone to Las Vegas to use his super-power to cheat the casinos. He is replaced in the team by ladies' man Rudy, an old flame of Alisha, who has the ability to twin himself - somewhat unwittingly - when stressed. This incurs the wrath of pick-up Tanya who believes he is two-timing her and who gets her revenge by killing Charlie, the girl she saw Rudy kissing, and framing him for the murder. Fortunately the second Rudy comes to the rescue after Tanya is accidentally killed and once more the misfits find themselves burying two bodies and hoping to get away with it.

Banned from athletics for drug use Curtis sees the opportunity to still compete as his new gender swap identity Melissa, whilst falling for fellow runner Emma. Emma is bi-sexual and is drawn to both Curtis and his alter ego Melissa but, with only Simon let into the secret, Curtis/Melissa becomes the reluctant object of the sexual attentions of Shaun, Rudy and running coach Mark, who spikes Melissa's drink at a party and tries to rape her, getting a rude shock when Curtis returns. Eventually Curtis is forced to admit the truth to the other misfits and, having saved her from Mark's predatory actions, to Emma.

In his alter ego as Super Hoodie Simon saves comic book fan Peter from a mugging. Later Peter recognizes his protector from his voice and the boys become friends, Simon explaining his destiny to become his future self by dying whilst saving Alisha. Peter, obsessed with his hero, uses his sinister gift to stop this - he draws cartoons in which the events come to pass in reality - and the pair have a climactic fight after Peter has abducted Alisha, though his comic strip reveals that he knew the outcome. Shaun meanwhile discovers Rudy's ability to clone himself whilst Kelly learns that Seth is still carrying a torch for the girlfriend whose death he caused when he was a drug dealer.

Elderly Jew Friedrich Hirsch travels back to 1930s Berlin to kill Hitler but fails and the Nazis use his mobile phone technology which alters history so Germany wins the war and present day Britain is under Nazi control, and none of the misfits know each other. Kelly and Simon are reluctant conscripts whilst Shaun, with Alisha, his unwilling girlfriend, is right hand man to odious Captain Smith. Seth, his ability to give and take super powers an asset to the Nazis, is imprisoned but Kelly and the other misfits spring him, leading to a shoot-out.

Kelly is accidentally body-swapped with a coma patient. Rudy gets anger management therapy.