A husband and wife are carjacked and she later ends up dead and her husband is wounded. The husband is the oldest brother of a family that owns a very good business.

Pool employee Armando Diaz's bloodily battered corpse is found in Craig Seaborn's 5-star hotel Graciana's gardens. He was killed in the penthouse, where three wives had a 'husbands nor sex' weekend. Beth Jacobson admits she had sex with him, but when he called her too unattractive to get hard a fight ensued, so she struck him with a towel bar, thrice. He also had safe sex with Felicia Hardy, who claims she didn't realize he was badly wounded when passing out after hitting his head against the bed. Wolfe follows a third blood trail, to the staircase and more suspects. It must all be tied in. Meanwhile chief James Burton warns Horatio his team is under scrutiny, just now there are tensions about sticking up evidence kits, labor division and Wolfe's media ambitions, apparently paying off a TV reporter.

A killer who has it out for Horatio surfaces in Miami, and frames him for a murder.

New technology on DNA testing reveals that a man convicted of a rape six years back is innocent and he is promptly released. Now a free man, he is eager on pressing charges against the department and the crime lab for his false conviction. Meanwhile, Horatio and his team reopen the case in hope to catch the real rapist. In the morgue, Alexx examines the body of a young woman who died from infections caused by a piece of cloth left inside her after an operation. She is intent on finding the surgeon responsible for this untimely death.