Nurse Jenny Lee arrives at Nonnatus House in London's East End to begin her work as a midwife. Naive and unused to the harsh conditions of the borough, she must rise above her misgivings if she is to succeed in her new role.

A new midwife, Chummy Browne, arrives at Nonnatus House, and finds it difficult to prove herself. Meanwhile, Jenny befriends a young Irish prostitute who is expecting a baby, and is shocked by the Church's treatment of the girl.

Jenny befriends an old soldier named Joe, and is disturbed by his living conditions. She is also visited by a man from her past, while Trixie and Cynthia have a sensitive case to deal with, and Chummy is asked on a date.

A new baby is snatched from her pram, sparking an area wide search. Jenny is more familiar with the kidnapper than she realizes, Cynthia blames herself when a patient becomes gravely ill, and Chummy's romance continues.

A figure from Jenny's past makes contact, while Jimmy continues to pursue her. Chummy prepares for an important meeting, and everyone at Nonnatus House rallies round the building's cleaner, Peggy, whose brother is very ill.

Jenny speaks to her ex-lover again, while Sister Monica Joan lands herself in trouble with the police. Chummy receives a visit from her snobbish, imperious mother which forces her to reconsider her relationship with Peter.

Nonnatus House is alive with preparations for Christmas. Chummy is arranging a nativity play with the Cub Scouts, Jenny is faced with a difficult case, and a young girl's predicament leads to a big decision.

Jenny tries to help a battered wife, Doctor Turner finds himself overcome with requests for nitrous oxide from pregnant women throughout Poplar, while Trixie and Sister Evangelia help deliver a baby in very unsavory circumstances.

Chummy makes an important decision, Jenny reconnects with Jimmy, and Cynthia's conduct is called into question after the death of a baby she delivered.

Hesitant nursing assistant Jane Sutton arrives at the convent as Jenny is seconded to hospital work, meeting Jimmy, who, to her surprise, is one of the patients. Arrogant surgeon Aubrey Tracy misdiagnoses Jimmy and an operation is required, where Jenny acquits herself well. She also sees that Tracy is himself ill and he resigns. Meanwhile aggressive twins Meg and Maeve Carter - both married to the hen-pecked Sid - arrive at the clinic as Maeve is pregnant. However they eschew modern medicine for old herbal remedies and, following a bleak tarot card reading, the over-bearing Meg scares her sister into refusing hospital admission. Ultimately Maeve senses that she needs professional care and allows the midwives in for a home birth - where a new generation of twins is born.

A friend of Chummy's, Reverend Applebee-Thornton, comes to stay at Nonnatus House and soon gets on everyone's nerves. Meanwhile, Jenny and Sister Evangelina deliver a baby with spina bifida, and Sister Bernadette plays matchmaker.

Nonnatus House prepares for the annual summer fête, but when a baby show is announced, the girls must find a host for the proceedings. Meanwhile, a patient of Jenny's puts her life at risk, and Sister Bernadette remains troubled.

Doctor Turner is concerned by the spread of tuberculosis in the community, Jenny tries to repair a father and daughter's fractured relationship, and Sister Bernadette receives devastating news.

Jenny encounters racism firsthand when assigned a Jamaican patient, while Cynthia has to deal with a cantankerous man suffering from diabetes. Sister Bernadette avoids Doctor Turner, and a familiar face returns to Nonnatus House.

Sister Bernadette is discharged from hospital, while a heavily pregnant Chummy resumes her midwifery duties. Jenny meets a new love interest, Fred's pregnant daughter pays him a visit, and Nonnatus House itself is under threat.

Nonnatus House and the surrounding area is evacuated when an unexploded bomb is found nearby. Meanwhile, Shelagh has doubts about her wedding to Patrick, and Jenny and Trixie help a man who is suffering from shell shock.

Now dating surveyor Alec, Jenny joins the other midwives in their superior new base, along with latest recruit, Sister Winifred. Jenny is concerned for Merle and Billy, a young couple whose infant boys are permanently ill, causing them to doubt their parenting skills, whilst added is stress provided by the fact that Billy's brother died as a toddler. Surprisingly, Sister Monica Joan accidentally provides Dr. Turner with the solution to the children's complaints, thus saving them. Chummy, meanwhile, drums up support for the newly opened, but under-used ante-natal clinic, taking advantage of a royal visit to put it in the spotlight. The day is a success, and to add to it, Chummy helps an older woman with a difficult birth, resulting in Sister Julienne asking her to return to work.

Jenny is promoted to Acting Sister at the clinic, much to the chagrin of the more experienced Trixie. Meanwhile, Cynthia is taken in by the theories of a visiting doctor, and a troubled, desperate woman seeks help.

Sister Julienne and Trixie attend to the female inmates at Holloway Prison, where they meet a troubled young woman. Meanwhile, Jenny deals with a vain patient, Shelagh receives horrendous news, and the girls celebrate Chummy's birthday.

Sister Winifred treats a young Jewish woman whose mother is plagued by remembrances of the Holocaust. Meanwhile, Shelagh tries to find a new way to channel her energy, and Alec suffers a terrible accident.

As Jenny takes compassionate leave after Alec's death and Sister Julienne collapses with exhaustion Shelagh returns to help out and efficient nurse Patsy Mount arrives. They start to plan for a party to mark the jubilee of Sister Evangelina taking holy orders but are interrupted by irate Mrs Harper, whose daughter Sally, a young woman with Downs Syndrome, is pregnant. The father, cerebral palsy sufferer Jacob, lives in the same residential home and they declare that they are in love and aim to marry but the baby is stillborn and Jacob is sent to another home. News of Evangelina's celebration attracts her brother Vincent, now an alcoholic tramp, and she steals food for him and sees him admitted to hospital, but her party goes ahead - despite her protests - and the community shows their appreciation of her work over the years.

Patsy's brusque manner sees her taken off midwifery duties and reassigned to district nursing, where a patient reminds her of her past. Meanwhile, Trixie deals with a couple whose relationship has separated them from their families.

Jenny returns and is seconded to the London Hospital, where she meets a fretting mother-to-be. Meanwhile, Chummy's mother visits, a patient of Cynthia's becomes mentally ill, and Tom's nervousness leads to trouble with Trixie.

Chummy struggles to cope with her mother's terminal illness, with her experience affecting Sister Monica Joan greatly. Meanwhile, Shelagh and Patrick receive encouraging news, and Jenny makes an important decision.

As Christmas approaches, Chummy and Trixie are organizing a concert. Meanwhile, Patsy takes a pair of pregnant girls to a mother-and-baby home which proves to be ill run, and Cynthia is conflicted about her future.

A new midwife arrives at Nonnatus House, and finds it hard to fit into her new role. Meanwhile, Chummy moves into the mother-and-baby home, Trixie helps a young boy in terrible need, and Sister Evangelina is in denial about her illness.

As Sister Evangelina prepares to go on sick leave, a new midwife arrives at Nonnatus House, and they immediately clash. Meanwhile, Sister Julienne encounters a face from the past, and Barbara feels under pressure.

As dysentery sweeps through the area Trixie takes on her first official duty since her engagement to vicar Tom by organizing the Rose of Poplar contest whilst Phyllis is concerned for sickly Dolores McEvoy, who is living in a filthy hostel apart from her husband but is too ashamed to give the address. When Phyllis locates the hostel she also finds the source of the dysentery. Meanwhile young father-to-be Tony Amos is the victim of police entrapment when he goes cruising in a men's toilet. Dr Turner speaks up for him when he is taken to court but, although prison is avoided, bigoted attitudes make life difficult for him and his wife and the nurses' opinions are divided.

Sister Winifred meets a young prostitute and begins a campaign to improve the lives of women like her, Trixie reconsiders her engagement when Tom is offered a post in Newcastle, and Sister Monica Joan is unexpectedly called into action.

Sister Mary Cynthia returns to Nonnatus House, Barbara has trouble communicating with a pregnant Sylheti woman, Shelagh helps Patrick with his exhausting workload, and Trixie struggles to cope with her pain.

Phyllis deals with a diabetic teenager who has fallen pregnant, Sister Mary Cynthia comes into contact with a group of Irish Travellers, and Patsy organizes a square dance to raise money for the Cubs' trip to Norfolk.

A pair of school friends are unexpectedly reunited in the delivery room, and a mix up results in complications for both. Meanwhile, Barbara helps a couple in need of assistance, and Patsy's secret relationship with Delia pains them both.

Trixie and Sister Mary Cynthia help a deaf-and-dumb woman, and Barbara has a baffling case. Meanwhile, Fred's daughter arrives from Birmingham and interferes with his and Violet's engagement, and Delia has a proposal for Patsy.

As Christmas approaches, an outbreak of measles hits Poplar. Meanwhile, Tom receives an intriguing offer from the BBC, a face from Patsy's past returns, and Sister Monica Joan goes missing.

As Easter approaches, the nuns prepare for celebrations, Trixie is taken up with a new exercise class, Patsy awaits Delia's decision, and the group are shaken by the birth of a severely deformed baby.

Barbara has difficulty in working out how best to help a young woman whose husband is out of work, Sister Evangelina's strong opinions lead to trouble, and Phyllis attends a Spanish class, with unexpected results.

One of Patsy's patients is diagnosed with typhoid, which reignites painful memories, Sister Winifred is deeply affected by the case of an unwed mother-to-be and Tom asks Barbara out to dinner.

Tom and Trixie work together to help a young couple, Barbara wrestles with her conscience, and Sister Julienne is seconded to a maternity hospital, where she discovers the emergence of a worrying pattern.

Phyllis becomes concerned about a new mother who is finding it difficult to cope, Fred must step in to help run the shop when Violet is injured, while Timothy makes Patrick have a realization.

A series of attacks on young women in Poplar has a direct impact on the residents of Nonnatus House, Trixie is suspicious about a patient whose pregnancy has not been reported, while Patrick and Shelagh take a trip.

As news of the forthcoming contraceptive pill reaches Poplar, it is met with different reactions by the residents of Nonnatus House. Meanwhile, Patsy tries to help a barge woman unused to life on land, and a storm hits Poplar.

Patrick is horrified to learn that a medication prescribed to expectant mothers may be the cause of the recent birth defects in Poplar, while the Nonnatus House residents and the community at large are devastated when tragedy strikes.

A group from Nonnatus House travels overseas in order to assist a struggling clinic in South Africa.

The Nonnatus House staff face great change, Phyllis and Barbara help a battered wife, while Sister Mary Cynthia becomes increasingly fragile.

An explosion at the docks badly affects the husband of a new mother, Patsy feels under pressure, and Sister Ursula continues to test the patience of everyone at Nonnatus House.

Sister Ursula continues to make life difficult for the staff of Nonnatus House, while sweeping reforms place the maternity unit under threat.

Nonnatus House advertises for a new midwife, while Trixie, Sister Winifred and Tom help an expectant mother in a difficult situation.

Nonnatus House welcomes a new recruit, Fred and Violet take in a vulnerable young man, Sister Monica Joan makes a discovery, and Trixie meets a charming dentist.

As the Cuban Missile Crisis brings fear to Poplar, Sister Julienne tries to arrange the return of Sister Mary Cynthia, while Valerie deals with a very challenging case.

The effects of thalidomide continue to take their toll on a former patient, leaving Patrick guilt-ridden, while a shocking incident leaves Phyllis consumed with guilt of her own.

A new contraceptive clinic adjacent to the Nonnatus maternity unit causes trouble, while an unexpected letter to Barbara sends everyone into a frenzy.

As the year comes to an end, Poplar faces unprecedented and relentless wintry conditions, which pose a challenge to the occupants of Nonnatus House and the community at large.

As the Big Freeze of 1963 continues, Nonnatus House welcomes their newest midwife, while contending with the effects of the weather.

As Lucille settles into her duties, she faces prejudice from a patient's mother, while Sister Winifred opens her mothercraft classes up to fathers, and the Turners meet their new au pair.

A patient of Phyllis' receives a devastating diagnosis, Fred and Violet organise a beauty pageant, Magda discloses a secret, and Trixie makes a tough decision.

Trixie battles her demons and Sister Monica Joan faces losing her eyesight, while Sister Julienne assists a childless Pakistani woman after her husband is pressured to marry a second wife.

The fear of a potential smallpox outbreak grips Poplar, Lucille helps a woman with a phobia of childbirth, and the Buckles organize a charity picnic.

A recently widowed expectant mother faces hardship, Valerie and Lucille's teenage health class is met with opposition, and Sister Monica Joan prepares for her cataract surgery.

The Turners attempt to improve the life of a young man from a remand home, Lucille finds unexpected friendship, while Nonnatus House is filled with worry for Barbara.

A nearby maternity home closes, bringing new patients to Nonnatus, while Tom deals with his grief and Sister Monica Joan is given a surprise.

As Christmas approaches, Sisters Julienne and Winifred are called to the Mother House, where important decisions must be made. Meanwhile, Trixie returns from Italy, and the midwives help with a difficult birth.

As two new nuns join Nonnatus House, a shocking case exposes the seedier side of Poplar, while a complicated birth tests Trixie and Phyllis.

As Violet runs for election as a councillor, Lucille befriends an elderly woman facing eviction, and Sister Hilda supports a Ghanaian family suffering from a mysterious illness.

A troubled mother receives support from Shelagh and an unexpected source, Valerie helps a woman whose child is born with a cleft palate, and Phyllis has ambitious plans for the Whitsun bank holiday.

A friend of Trixie's finds herself in an impossible situation, while Sister Julienne endeavors to mend a fractured-mother daughter relationship.

A young bride-to-be suffers an identity crisis after the diagnosis of a hidden condition, an expectant father is diagnosed with a rare condition himself, and romance is in the air for Lucille.

When Phyllis is admitted to hospital, Mother Mildred returns to cover her assignments, and soon causes a stir, while Lucille cares for an unwed teenager who wants to keep her baby.

A woman's pregnancy is affected by her husband's infidelity, Sister Frances faces her first solo delivery, Shelagh receives news about May, and Valerie's loyalty is tested.

As Shelagh plans a ball to raise money for new medical equipment, Valerie must come to terms with recent events, while Sister Hilda assists a terminally ill young woman.

The midwives answer the call for medical help in the Outer Hebrides.

In January 1965, a diphtheria outbreak sweeps through Poplar and Mother Mildred seeks to help a distraught woman who abandoned her newborn.

Sister Julienne intervenes in the case of a pregnant prostitute, a family's plan to leave Poplar are up in the air when a mysterious illness strikes, and Sgt. Woolf faces a health crisis of his own.

Lucille encounters a defiant expectant mother who is less than kind, Phyllis attempts to help an immigrant mother with an alarming medical condition, and Shelagh and Trixie put on a fashion show to raise funds for the maternity home.

Nonnatus House welcomes four male junior doctors to live and work among the midwives while Fred tries to help a sick man whose home is to be demolished.

The plight of a harried matriarch profoundly affects Sister Julienne and Sister Frances, while Sister Hilda helps a nervous expectant father.

Valerie's cousin Maureen endures a difficult labor and subsequent issues, while the Turners' adoption of May comes under threat.

Trixie helps a blind mother care for her new baby, Kevin makes an error which troubles Sister Frances, and Valerie becomes concerned for her grandmother.

The local council threatens to cut funding to Nonnatus House, which may face demolition. Two pregnant women discover they have something surprising in common.

Sister Monica Joan is rushed to hospital, while Trixie is less than impressed to receive a subscription to a Marriage Bureau as a Christmas present. Meanwhile, the circus is in town.

Sister Julienne and Doctor Turner clash over whether to provide a private care service. Then a distressing birth raises fears of another Thalidomide case.

Sister Frances finds herself in a tricky situation when a pregnant woman confides in her. Cyril helps a family find shelter after they are evicted from their home. Sister Julienne's new venture hits a stumbling block.

Sister Hilda and Doctor Turner are involved with a young woman whose health presents a series of challenges. A complicated pregnancy leads the Nonnatus House team on a path of discovery.

As the World Cup draws near Fred places a risky bet on the final. Nonnatus House welcomes four new pupil midwives, Dr Turner meets a 17-year-old boy harboring a desperate secret, and Cyril and Lucille's relationship continues to blossom.

With sister Julienne away on a refresher course, sister Hilda steps in to carry out home visits. The new pupil midwives are settling in well, and there is a sense of hope in the air. While examining expectant mother Vera Sands during a routine visit, sister Julienne is concerned by her toddler daughter who is displaying troubling symptoms. Determined to find out what's wrong, sister Julienne and Dr Turner are on the case. Meanwhile, an overly protective mother struggles to cope with her daughter's teenage pregnancy and is insistent on keeping it low key, much to the frustration of new pupil midwife Nancy Corrigan.

Trixie stirs up controversy in the community when she speaks out on behalf of a patient who is pregnant with her fifth child, but whose personal life is far from stable. Dr Turner and Sister Frances try to help a woman who is refusing medical treatment through the last weeks of her pregnancy, and Nancy reveals a secret about her background that could threaten her relationship with Nonnatus House.

The Nonnatus House staff struggles to come to terms with Nancy's revelation. Sister Frances and Trixie rally the others to take a stand and do something about Poplar's growing housing crisis. Sister Hilda relishes taking charge when Sister Julienne takes her annual leave, Timothy Turner prepares to leave for medical school, and Cyril is forced to reconsider his future after he receives news from home. A very special baby is born, causing a rift in a close-knit family and leading many people to count their blessings.

Lucille and Cyril are excited about their wedding but as the day approaches, nothing seems to run smoothly, and the ceremony itself is put in jeopardy.

Demolition work in Poplar uncovers a long-buried secret that leads to a testing and emotional case for the team. Sister Julienne takes on a sensitive delivery.

At the monthly cytology clinic, Sister Frances comforts a young woman who is struggling with a life-changing diagnosis. Lucille supports a difficult mother.

Shelagh organizes a special celebration to mark 100 years since the Order first arrived in Poplar - although Sister Hilda feels that she should have been in charge of the festivities.

Sister Hilda and Dr Turner supports a young father with a lung condition and Trixie takes the lead with a struggling first-time mother.

Trixie has been assigned to a complicated case involving a crane driver who was injured in a workplace accident and is now paraplegic. Meanwhile, Nancy and Sister Frances give a talk on the facts of life at a primary school.

Sister Monica Joan seeks advice from a clairvoyant. Matthew is shocked to discover squatters in one of his warehouses, and Shelagh faces the most challenging delivery of her career.

An unforeseen event in Poplar means that Nonnatus House suffers its biggest threat yet. But this time it's not the bricks and mortar that are in danger - it's the people.

Nonnatus House faces its darkest day after a tragic incident in the heart of Poplar. As the community rallies together, the team must overcome personal anguish to help the injured.

It's April 1968 and change is coming to Nonnatus House. Racial tensions cast a shadow over Poplar, and the sisters welcome a new recruit.

The Turners support a family still suffering the devastating effects of thalidomide, Miss Higgins is involved in an unexpected delivery, and the community stages a talent show.

At a coffee morning for expectant mothers, Sister Julienne meets heavily pregnant Lilian Reynolds, who is expecting her first child.

Sister Veronica is shaken when a mother reveals a terrible truth about her marriage. Shelagh cares for a baby with a life-threatening condition, and Nancy harbours a secret.

The maternity home is thrown into chaos by an outbreak of gastroenteritis, and Nurse Crane fights to save her career. Meanwhile, Cyril encourages Reggie to seek help.

A pregnant mother with a chronic heart condition falls unwell. Nancy grows suspicious of a young father's erratic behaviour, and Matthew prepares for a visit from his father.

Trixie supports an underage mother through a difficult time, Monica Joan welcomes an unusual guest to Nonnatus House, and Sister Veronica spearheads a new council initiative.

Nancy makes a home visit to Imelda O'Connor, and is surprised that Imelda, her husband Maurice and young son Paul are living in a cramped caravan on a building site.

Dr Turner experiences the biggest test of his career, while Trixie's approaching nuptials cause stress levels to escalate. Sister Julienne hatches a plan to save Nonnatus House.

Jenny is promoted to Acting Sister at the clinic, much to the chagrin of the more experienced Trixie. Meanwhile, Cynthia is taken in by the theories of a visiting doctor, and a troubled, desperate woman seeks help.

In January 1965, a diphtheria outbreak sweeps through Poplar and Mother Mildred seeks to help a distraught woman who abandoned her newborn.

One of Patsy's patients is diagnosed with typhoid, which reignites painful memories, Sister Winifred is deeply affected by the case of an unwed mother-to-be and Tom asks Barbara out to dinner.

Nonnatus House welcomes four male junior doctors to live and work among the midwives while Fred tries to help a sick man whose home is to be demolished.

A new midwife arrives at Nonnatus House, and finds it hard to fit into her new role. Meanwhile, Chummy moves into the mother-and-baby home, Trixie helps a young boy in terrible need, and Sister Evangelina is in denial about her illness.

Patsy's brusque manner sees her taken off midwifery duties and reassigned to district nursing, where a patient reminds her of her past. Meanwhile, Trixie deals with a couple whose relationship has separated them from their families.

A group from Nonnatus House travels overseas in order to assist a struggling clinic in South Africa.

An unforeseen event in Poplar means that Nonnatus House suffers its biggest threat yet. But this time it's not the bricks and mortar that are in danger - it's the people.

As the World Cup draws near Fred places a risky bet on the final. Nonnatus House welcomes four new pupil midwives, Dr Turner meets a 17-year-old boy harboring a desperate secret, and Cyril and Lucille's relationship continues to blossom.

Lucille and Cyril are excited about their wedding but as the day approaches, nothing seems to run smoothly, and the ceremony itself is put in jeopardy.