Lex is committed to the Belle Reve Sanitarium for the criminally insane by Lionel who forces the shrink, Dr. Claire Foster, to submit Lex to an experimental electroshock therapy technique to erase his memory and forget his past events. Clark visits Lex and after finding out, decides to try to save his friend, despite protests from Jonathan and Martha that Clark's secret is known by Lex. But three of Clark's adversaries reside in Belle Reve. They are the arrogant, power-stealing Eric Summers (from episode "Leech"), the angry, meteor-rock mutant racist Van McNulty (from episode "Extinction") and the double-clone Ian Randall (from episode "Dichotic") who join forces to attack him so Eric can steal Clark's powers again and and escape from the asylum. Meanwhile, Lana begins to distance herself from Clark while she's attending physical therapy to recover from her broken leg with the support of a charming patient named Adam Knight (Ian Somerhalder).

Lex is targeted by a former Belle Reve patient who can move through frequency, and who wants him to come clean about 33.1. Meanwhile, Clark goes to Seattle to hunt down one of the Phantom Zone escapees.

Clark is far from impressed that Lois barely dares rebuke her kid sister's mean pranks on both of them, while squirming for each, even offensive, whim of Pa, full general Sam Lane, as their Thanksgiving guest. Clark firmly but politely hosts the Lanes, while reasoning against the general's support for a bill to make 'registration' compulsory for superheroes, an obvious trap given the congressional supporters' antecedents. While Oliver investigates them, Clark saves everybody from proponent Rick Flag's Machiavellian rocket attempt on the general's life. Only when Lois finally sides with Clark against Pa, he reveal his ulterior motive for exaggerated rudeness.