Joey travels to Boston to visit A.J. where he is about to receive a critic writing award and meets his childhood friend, Morgan, whom Joey sees as a clone version of herself and her growing feelings for Pacey. Back in Capeside, to avoid suspension, Pacey becomes a mentor to a nine-year-old boy, named Buzz Thompson, and must contend with the kid whom is a little version of himself: a neglected and abused little boy - with a big attitude. Meanwhile, Dawson asks Mitch to help as a chef with the opening of Gail's restaurant which makes Gail angry as she wants nothing to do with her ex-husband.

The year is 2008. After five years, the gang returns to Capeside for a reunion and wedding after taking different paths in life. Joey is a successful book editor living in New York with her current boyfriend Chris. Dawson lives in Hollywood and is a successful executive producer of his autobiographical TV series, 'The Creek.' He is still single, but has not forgotten the love of his life. Pacey is now the manager to the re-opened restaurant, The Ice House, but still continues his brash lifestyle of dating older women. Jack is now a teacher at Capeside High and dating Pacey's brother Doug, now the sheriff, who is still closeted. Jen lives in New York with Grams and runs an art gallery in SoHo, and is now the mother of a baby girl, while Audrey has gone off to Europe on tour with a band. They all (sans Audrey) meet at Pacey's restaurant, and after a little too much wine they all start bringing back ghosts from the past. They all get dressed and ready for Gail's wedding, and between old memories and new bruises (from Pacey, who was beaten up by some married woman's husband), Joey tries to balance having the two men that changed her life around her. Suddenly, Jen faints and is taken to hospital, where Grams reveals that she suffers from a lethal heart condition. Jen is dying...