Dr. Shaun Murphy suspects his patient is lying about the reason for her injury and makes a controversial assumption about her motives. Meanwhile, Dr. Neil Melendez's personal life could be affecting his work and, ultimately, his patients lives.

Dr. Lim proposes a plan to encourage healthy competition between the residents. Dr. Melendez along with Dr. Brown and Dr. Resnick treat a father of twin girls who has appendicitis but complications occur when his the doctors discover he's taken too much extra medication. Morgan and Claire get to know each other's differences and develop a rivalry Dr. Lim along with Dr. Murphy and Dr. Kalu treat a young transgender girl who has testicular cancer. Murphy learns to accept that you aren't confined to the gender you're born with. Doctor Andrews and his wife see a fertility specialist to help with their problems conceiving.

When the team treats a patient who has to decide about getting a dangerous surgery that could change his life, the man asks Dr. Murphy what he would do.

Dr. Shaun Murphy questions the need for an elective surgery that will allow his young patient to smile for the first time. Meanwhile, Dr. Claire Brown and Dr. Morgan Reznick discover that their patient lied about her identity.