Vincent Chase is a young, hot, up-and-coming actor living in Hollywood. Tonight, he must attend the opening of his latest movie "Head On," but first he and his three best friends from back home (Queens, NY) have lunch and discuss their upcoming 10-year high school reunion. Vince is reluctant to go but his buddies urge him to go with them. At the post-premiere party, Vince's agent, Ari, hassles Eric about getting Vince to read the script for a possible new project. Over breakfast, Vince says he's not going to do "Matterhorn" on Eric's advice. The foursome goes to meet with the director where Vince impresses him so much that Ari calls later to tell him that they've offered $4 million for the part. While Turtle and Drama celebrate, Vince lets him know that Eric is not too enthused about the script. Later, Ari and Eric share a rather confrontational dinner while discussing the future of their star's career. After Vince decides to take Eric's advice not to do the movie, the boys leave for their reunion. Before they can drive off, though, they get a call with some bad news: Colin Farrell has taken the part.

Ari wakes Eric with a phone call to remind him that tonight is the all-important opening night for Vince's movie. Immediately after Eric hangs up, Emily unexpectedly drops off fan mail, but with ulterior motives. Drama introduces the guys to his latest lady friend back at the house and then they discuss their plans for the evening over breakfast at a diner. Vince's major work for the day is a stop at Big Boy's Neighborhood, a local radio show. As a result of the appearance, Vince secures a date for himself with Justine Chapin. While everybody gets ready for the night's activities, Ari video conferences with Eric to tell him that matinée numbers for Vince's movie have been "less than stellar" because it is in direct competition with the latest Pixar feature. Kristen also calls to confess to Eric that she might still harbor feelings for him. Turtle resorts to desperate measures to get a date for their night of bowling, and it does not go unspoiled. After bowling, the large group makes a stop at a night club where, one by one, the boys find themselves alone. The night does not end on a bad note, however, and Ari arrives with some good news.

Things appear to be back to normal. While the boys wait at a coffee shop for a meeting with Ari, they all give Eric a hard time about leaving Emily a drunken message the night before. Drama is in good spirits because he has some money to burn after getting residuals from his brief stint on "Pacific Blue". Ari has arranged a "meet & greet" with the director of "Queens Boulevard", so the group heads to the infamous Chateau Marmont. The outcome of the meeting is hazy: Vince likes Billy, but Eric is getting a bad feeling, and they walk away with a script that he has made revisions to. The revision that causes the most uproar begins to cause some tension among the ranks. Shauna lets Eric know that Vince's sex symbol status could be on the line if he chooses to go forward with this movie. Eric makes a secret phone call to Ari to express his concern. After hearing some reassuring wisdom, the boys screen Billy's previous film, which was a huge hit at Sundance. Amazingly, they all like it. The next day, handshakes are exchanged, and the decision is made to entrust the film to Billy Walsh.

The boys are starting to get low on cash and to help pay the bills; Ari lands Vince a gig appearing in a lucrative foreign commercial. Meanwhile, Turtle decides to make his own money by entering an Xbox boxing tournament, but he gets ousted early on by a young gaming prodigy. Eric needs to get a copy of "Queens Boulevard" to James Cameron so he can see Vince's work, but Walsh refuses to screen it before he shows it at Sundance. Luckily, the A-list director agrees to attend the Sundance screening of the film, offering hope that Vince may still end up with the "Aquaman" role.