Eleven years after the events of the Clerks, Dante Hicks (Brian O'Halloran) opens the Quick Stop convenience store to find that it is on fire; Randal Graves (Jeff Anderson) had left the coffee pot on after closing the night before. As a result of the destruction of Quick Stop and the adjacent RST Video, Dante and Randal begin working at a Mooby the Golden Calf fast food restaurant along with Elias (Trevor Fehrman) and their manager List of View Askewniverse characters#Becky Scott (Rosario Dawson). A year later, Dante is planning to leave his minimum wage lifestyle in favor of a family life in Florida with his fiancée Emma Bunting (Jennifer Schwalbach Smith), whose father will provide them with a home and a business to run. This leaves Randal, who fears that with Dante moving to Florida would leave him without his best friend, bitterly disappointed. Jay and Silent Bob (Jason Mewes and Kevin Smith) have since followed Dante and Randal, and now loiter outside of Mooby's. Jay and Silent Bob no longer do drugs after they were arrested for possession and were sent to Drug rehabilitation, and become devout Christians following their release. However, the duo continue selling drugs.

Competition between the maid of honor and a bridesmaid, over who is the bride's best friend, threatens to upend the life of an out-of-work pastry chef.

A night debauchery in Las Vegas goes massively awry when three groomsmen lose their best friend during his bachelor party, just days before his impending wedding.

Patrick returns to San Francisco in search of closure and resolution regarding his relationships with Richie and Kevin.

A guy and girl try to keep their relationship strictly physical, but it's not long before they learn that they want something more.

A young man who works as a Bar Mitzvah party host strikes up a friendship with a mother and her autistic daughter.

Four socially troubled 18-year-olds from the south of England go on holiday to Malia.

John Bennett, a man whose childhood wish of bringing his teddy bear to life came true, now must decide between keeping the relationship with the bear, Ted or his girlfriend, Lori.

After they are forced to live next to a fraternity house, a couple with a newborn baby do whatever they can to take them down.

Jim, Oz, Kevin and Stifler are back -- and hornier than ever! After their first year of college, they reunite and rent a beach house for the summer.

Alison Scott, a career-minded single woman meets slacker Ben Stone at a local nightclub. After a night of drinking, they end up pregnant and together the two must deal with the repercussions.

A New Jersey guy dedicated to his family, friends, and church, develops unrealistic expectations from watching porn and works to find happiness and intimacy with his potential true love.

While on a date in a fancy restaurant with Michelle, Jim is ready to propose to her. His father calls to inform him that he has the ring. Michelle misinterprets when Jim stalls the question. Jim's dad arrives as Jim is receiving fellatio, and a mishap grasps the restaurant's attention. Jim proposes and Michelle accepts.

Pete and Debbie are both about to turn 40, their kids hate each other, both of their businesses are failing, they're on the verge of losing their house, and their relationship is threatening to fall apart.

Composer Peter Bretter (Jason Segel) is in a five-year relationship with actress Sarah Marshall (Kristen Bell), who stars in a ''CSI: Crime Scene Investigation''-like television show titled ''Crime Scene: Scene of the Crime''. One day, as Peter stands stark naked in their apartment, Sarah announces that she is breaking up with him. Devastated, and unable to banish his grief through one-night stands, Peter takes a trip to Hawaii. However, the vacation is ruined when he learns that Sarah and her new rock star boyfriend Aldous Snow (Russell Brand) are also guests of the resort. Taking pity on him, hotel concierge Rachel (Mila Kunis) offers him an expensive suite for free in exchange for cleaning up the room himself.

As a cowardly farmer begins to fall for the mysterious new woman in town, he must put his newly found courage to the test when her husband, a notorious gun-slinger, announces his arrival.

Three scouts, on the eve of their last camp-out, discover the true meaning of friendship when they attempt to save their town from a zombie outbreak.

In 2002, an artistically inclined 17-year-old girl comes of age in Sacramento, California.

Inspired by a true story, a comedy centered on a 27-year-old guy who learns of his cancer diagnosis and his subsequent struggle to beat the disease.

A young man and woman decide to take their friendship to the next level without becoming a couple, but soon discover that adding sex only leads to complications.