When a young woman riding a horse finds a body of a woman inside a pipe in a construction site, Grissom and his team investigate the murder. Soon they find another woman's body and coroner Dr. Albert 'Al' Robbins notes that the women are very different despite being sisters. Their further investigation indicate the Donna Marks was a reclusive woman, maybe agoraphobic, while Joan Marks had a different behavior. Meanwhile, Catherine and Nick investigate the murder of the hunter James Jasper in the woods. James was an insurance broker and an experienced hunter, but was not wearing the safety vest. Catherine, Nick and Detective Vega learn that Jasper and his wife Linda had lost their jobs. When they find a one-million dollar life insurance on behalf of Linda, his wife becomes their prime suspect.

Dr. Langston confronts Nate Haskell one more time during his murder trial. Meanwhile, Nick faces an old teenage nemesis, Jason McCann, who is seeking revenge for his brother's death.

While the team discovers body parts of a man and a woman in a barn, a ransom video involving one of Nate Haskell's brides arrives at the crime lab. They soon discover that the two cases are actually connected.

Dr. Langston sets out on a vigilante mission after Nate Haskell goes to Los Angeles and kidnaps his ex-wife and kills her husband.