The team is called to a suburban house where the whole family, except the two daughters, have been murdered with no apparent motive.

The CSI team is summoned to investigate the death of the first-class passenger Tony Candlewell in twelve hours because of a jurisdiction problem. Candlewell has contradictory evidences of aggression and defense, and the first class passengers are secluded in the airport and interviewed. But Catherine and Brass note that they are hiding information. Meanwhile, in the autopsy, the coroner learns that Candlewell had undiagnosed encephalitis, the reason of his berserk behavior. When they find shoe prints on the back of his jacket, the passengers Lou Everitt, Max Valdez, and Dr. Kiera Behrle .are considered prime suspects. The team interviews the blind Mr. Cash that was near the incident and using dummies later, they represent the statements and come to a conclusion of the case.

Sara and Grissom investigate the death of a woman, Kaye Shelton, found wrapped in a blanket in the mountains. With no way to confirm the time of death, Grissom relies on the insects found on her body to establish a timeline. Catherine and Warrick work on a case of a stolen painting. Nick works solo on a case of a missing wife.

A bomb in a brief case goes off in the lobby of an office building. The team must piece together all the parts of this bomb to look for the maker's signature. Nick becomes involved in a crime after spending a night with a woman who ends up dead the next day.

The team arrives at a charity fund-raiser being held at the house of Portia Richmond, an ex-show girl who became very successful, where a body is found floating in the swimming pool. Portia herself is absent from the scene. The two hosts, Patrick and Amanda Haynes, claim that she is on vacation in Europe. Warrick works on a case of a mob shooting. The deceased is found in a glass elevator with a quarter stuck in the bullet wound on his forehead.

There's a serial killer on the loose in Las Vegas. Since this is a very high-profile case, the sheriff brings in the FBI to help. This annoys Grissom very much as the FBIs like to assume many things while he prefers to let the evidence speak for itself. Due to his refusal to cooperate, he is taken off the case. Grissom's team, however, knows better and keeps their boss informed on the details.

A construction worker falls off a tall building. Forensics determines that he died prior to the fall. Another case involves a boy who suffocates to death at his therapist's house late in the night.