It's his day off, but Mark shows up for work anyway. After a patient dies and Morgenstern wants to speak to him, Mark soon regrets coming in after all.

When a compatible bone marrow donor cannot be located, Scott Anspaugh agrees to undergo a new round of chemotherapy, even though there appears to be little point. Doug Ross suggests to Jeanie Boulet that Scott may have agreed to the therapy because of her. Mark Greene has taken on the task of organizing the annual ER banquet only to find that Jerry, on whom he had been relying for much of the preparation, hasn't quite delivered. John Carter confronts his grandmother when he learns that she has cut off funding for Carol Hathaway's free clinic. In the OR, Peter Benton has a major confrontation with Dr. Morgenstern, pushing him aside and taking over an operation. Greene and Weaver criticize Doug Ross over his handling of a sick child and her mother.

Even though he suffers from intense pain due to his stabbing injuries, Carter returns to work and prescribes a controversial procedure for a suicidal patient. Greene tries to convince his father to undergo cancer treatment.

Greene flies in a helicopter to a remote area of Indiana to rescue a heart transplant patient. The helicopter develops problems, and Greene arranges for paramedics to transport the patient to County. Because Weaver is gone for the day, Romano appoints Benton in charge of the ER. Kovac is plagued by the death of the mugger.

The ER is flooded with foster care home residents, attacked by a shooter bent on tracking down his son, who , with the help of Dr. Green, was put into the foster care system amid allegations he was being abused by his father.

Corday's ordeal, caused by the recent infection-related deaths of several of her patients, worsens when she is closely observed by a stern taskmaster. Corday is outraged when a county investigator accuses her of deliberately euthanizing the patients, who all happened to be elderly.

Abby comes close to breaking down trying to deal with her mother. Dr. Pratt goes for his required paramedic ride-along. Dr. Weaver confronts the man who stole her purse. Dr. Lewis has a teen admirer.