The team works to save someone close to a central character's heart. The key is inside House's head, but he is in a bad way himself.

House's investigator gets information on everyone, which House uses to stir the pot of their lives while the team tries to cure a portraitist whose artistic view now looks like Picasso.

House takes time to dabble in Cameron and Chase's love life while he treats an agoraphobic patient she's brought to the team.

A physician who gave up her career comes in for treatment, leading to tense encounters with the team. Meanwhile, Cuddy exacts revenge and Foreman's choice has devastating consequences.

House and his team treat a patient who had his brain split in half, now it seems like one side of his brain is causing some health/behavioral issues. House plays games with Cuddy over the night he detoxed, and those events will cause major changes. Cameron and Chase come to a decision.

After House's medical license is reinstated, he reclaims his role as Head of Diagnostics in time to treat Hank Hardwick, an adult film star admitted to Princeton Plainsboro for pulsating eye pain. Meanwhile, Cuddy is reminded that the hospital is not conducive to healthy personal relationships, and House angles to form a dream team.

A man with IQ 178 works as courier and collapses in a bookstore. House is still playing his games for Cuddy's attention. Chase punches him.

Physics student and his father, Artie, bring in the kid's lover Abby Nash, who nearly suffocated in foam during a planetarium lecture. The team eliminates everything except an allergy to something in her body. House presses Wilson to buy furniture as a way to express his personality.

A woman in an open marriage suddenly gets strong belly pain. Taub would like an open marriage. Wilson's new relationship with his ex is shaky.

The team takes on the case of an ailing groom-to-be who harbors undisclosed secrets from a previous relationship. As his fiancée tries to get answers to her many questions, a frustrated team winnows down the possibilities. Meanwhile, House spends extra-curricular time with his Princeton Plainsboro colleagues, performing a karaoke rendition of a Gladys Knight & The Pips classic with Foreman and Chase.

Science and faith are called into question when a patient is admitted to the hospital following his reenactment of the Crucifixion. The patient, Ramon Silva, refuses to undergo the prescribed treatment, and the team learns that after his daughter's cancer was cured, he pledged an oath of self-sacrifice to God. With little time to save Ramon's life, the team struggles to understand his reasoning and seemingly extreme religious convictions, but eventually learn that faith is not an argument. Meanwhile, Taub questions his wife Rachel about her relationship with an infidelity support group member and the team attends a co-worker's wedding where Wilson's relationship with Sam takes an unexpected turn.

When a woman falls on the subway tracks, Jack jumps down, saves her and faints. Martha finds him in ER. When the hospital uses Taub's photo for promotion, his wife's aroused. House meets Cuddy's mom.

Cuddy's mom has heart problems and is admitted. Secrets come out about her mom.

The team treats a patient with a secret home life. House enlists help to participate in a spud gun competition.

A known performance artist collapses during a performance. She ends with House's team, which is what she wanted. House is more self-destructive and irresponsible than usual. Cuddy's sister finds a date for her.

A teenage boy attempting to follow in his late father's footsteps as an entertainer is admitted to Princeton Plainsboro with partial paralysis. As the team searches for a bone marrow match, they uncover a disturbing family secret. Meanwhile, House looks for creative ways to remove his ankle monitor so that he can attend a boxing match in Atlantic City, and he treats a patient who is convinced he is suffering from diabetes. Also, Taub faces a tough decision when his ex-wife Rachel tells him that she wants to move across the country with their infant daughter.

Treating a drug addict patient results in House examining his life, his future and confronting his own personal demons.