A couple risk their lives getting from Cuba to see House, but his preoccupation with staff issues may cost the woman her life.

House's investigator gets information on everyone, which House uses to stir the pot of their lives while the team tries to cure a portraitist whose artistic view now looks like Picasso.

Taub treats a patient whose dying husband gets better as she becomes sicker, while the rest of the team deals with a devastating loss.

A wealthy businessman brings his teenage son, who is suffering from inexplicable stomach pains, to Princeton Plainsboro and insists on having Dr. House handle the case. The father of the patient believes the karmic penalty of his financial success is that he is victim to personal tragedy, and that the answer to his son's medical mystery lies in a reverse of fate rather than medical treatment. Meanwhile, Foreman and Chase prepare to present information on the Dibala case.

This is a hectic day in Cuddy's life from 5AM to 9PM. Giving an insurance company an ultimatum could bankrupt the hospital. She fires an employee for theft. Her child's sick. A patient won't pay for a reattached thumb.

A woman in an open marriage suddenly gets strong belly pain. Taub would like an open marriage. Wilson's new relationship with his ex is shaky.

Tension reaches new heights when Cuddy faces sobering news that propels her to reevaluate her priorities. While House is distracted by his concern for Cuddy's well-being, the team treats a teenage patient whose worsening symptoms and suspicious body scars indicate more than just physical illness. Sensing the teen's troubled emotional and mental state, Taub turns to the patient's personal life for clues and uncovers disturbing home videos that could put the lives of his peers in danger. Meanwhile, Cuddy remains hopeful that House will be fully present when she needs him most, and a series of dreams, including a musical scene choreographed by Mia Michaels, provide glimpses into her life and her relationship with House.

Cuddy dumped House. He moves into a luxury hotel and goes on a Vicodin, booze and cute hooker binge. The team gets a trampled rodeo bull rider but needs House to save him. Masters has a crush on their patient.

A known performance artist collapses during a performance. She ends with House's team, which is what she wanted. House is more self-destructive and irresponsible than usual. Cuddy's sister finds a date for her.

A prosecutor in court thinks he has a heart attack. Is it an anxiety attack? He has an arsenal hidden from his wife in their home. Taub tries to fix Foreman up with a nurse.

When a violent incident involving a patient has serious consequences for one staff member, House and the team are placed under review by Dr. Walter Cofield, Foreman's former mentor and current Chief of Neurology. As House and each member of his team recount the details of the dramatic and life-threatening incident, Cofield must weigh the team's unconventional brand of collaboration against their ability to save lives.

Chase is back. His first patient is a cute nun about to make her final vow. While still blaming House, he needs his help with his patient. House and Taub try to one-up each other with pranks.