With Marmee, accompanied by John Brooke, still in Washington with her sick husband , Jo takes charge of the household, taking Amy out of the school where she is bullied. Beth continues to visit the Hummels but contracts the scarlet fever rampant in the town, Amy being sent to stay with cantankerous Aunt March, but with their father's health still poor, the girls refrain from informing Marmee. Fortunately Laurie steps in to bring her home for Christmas, where the family has another pleasant surprise, and, for different reasons, Jo and Meg have cause to celebrate.

The war over Jo has some success as a writer but is annoyed when Amy is chosen over her to accompany an aunt to Europe and, with Meg giving birth to twins, feels side-lined, despite love-lorn Laurie's efforts to cheer her. She moves to New York to further her writing career and earn money to help sickly Beth, meeting the kindly Professor Bhaer, who is minding his orphaned nephews, but Jo returns home to take Beth to the seaside. Beth finally openly confesses that she is severely weakened by her illness and the family must prepare for the worst. A grieving Jo considers eschewing writing, but is dissuaded by her father and finds success professionally. With Professor Bhaer, who comes looking for Jo since she did not return to New York as promised, finds success personally, whilst Laurie discovers happiness with Amy.