The insecure Andrea Kuhn is encouraged by her psychiatrist to disclose her true feeling to her family, and when she is happy being herself, her husband accidentally kills her after an argument. Ruth recalls how stress triggered a depressive psychosis in George and his treatment with electroshock. Brenda has a miscarriage in the eve of her wedding day. Billy invites Claire to move to his place. David and Keith are discussing the alternative for their baby, adoption or to rent a belly. Rico misses a steady relationship while dating women from an Internet site.

While trying to reach the newspaper on the sidewalk, Samuel Wayne Hoviak, who was the best high-school friend of Nate, falls and his truck run over him. In the funeral service, Nate meets their other former best friend, Tom Wheeler; they recall their adolescence and realize that they are getting up. The bitter and deranged Ruth has no patience with George, and they receive his daughter Maggie. David proposes Claire to donate her eggs for the baby of his own with Keith, but she refuses. Claire feels her art rejected by the owner of a gallery and Billy misses his former personality. Rico dates Sharon and does not understand her hint that she does not want to see him again. Brenda begins an internship in a free clinic and does not support her first day, seeking Margaret's influence to help her to find a better place to work.