Lana tells Clark that she is moving to the Metropolis University and she is accepted in the Tri Psi Sorority, a sisterhood with hot vampires led by Buffy Sanders, and Lana is transformed in a vampire. Meanwhile, the chief-editor of The Daily Planet, Pauline Kahn, denies an intern position to Chloe, but in the end she proposes Chloe to write a good story to prove that she might be part of the team of reporters. Meanwhile, Lex intimidates Professor Milton Fine, but in retribution he shows a dossier about the secret experiments that Luthorcorp is performing in the campus of the Kansas University. When Clark sees Lana at Chloe's room, he believes she is with a hangover; later, he goes with Lana to a Halloween costume party promoted by the Tri Psi. When Lana attacks Chloe, Clark discloses the truth about Buffy and her sisterhood of vampires and tries to find a means to save Lana and Chloe when she gets bitten by the evil vamp Lana.

After a secret meeting with Lionel, Lana is shot at the Daily Planet by a mysterious gunman. Jimmy is knocked out while studying photographs of the scene and dreams about a 1940, black-and-white version, of Smallville. Jimmy finds himself playing the role of a reporter with Chloe his secretary, and a bumbling Clark also works there, as his sidekick. Jimmy's investigation leads him to Lana, who turns out to be a very evil femme fatale who plans to orchestrate the murder of her tycoon husband Lex by using Jimmy as the patsy. Jimmy's research further takes him to a notorious nightclub owned by Lionel Luther, and Lois is a sultry singer working at club who is having a fling with Lex to help him orchestrate the murder of Lana. Meanwhile, back in 2007, Clark discovers why Lana married Lex after Chloe learns it from Lana. Also, Lois further meddles in the shooting case by stealing a silver-lined cigarette case which holds a clue.