Sam and Dean Winchester were trained by their father to hunt the creatures of the supernatural. Now, their father has mysteriously disappeared while hunting the demon that killed their mother, 22 years ago.

Following visionary Sam's recent nightmare about the former Winchester home in Lawrence, Kansas, where the present dwellers, Jenny from Wichita and mother to two small kids, are suspiciously accident-prone, Dean reluctantly accepts to drive there. Dean and Sam reassure Jenny but follow up on the kids fear of a flaming creature in the closet. They consult Missouri Moseley, their father John's old medium friend, and together with the spirit of Mary Winchester, confront an evil poltergeist, but a second ghost intervenes and someone hides behind Missouri.

Dean is attacked by a Djinn and finds himself in a new reality where his mother is still alive and a mysterious woman holds the key to everything.

Sam and other "special children" are abducted by the Yellow-Eyed Demon and taken to a ghost town, where the ultimate battle must start.

Dean and Bobby have something frightening locked in Bobby's panic room: Sam, contaminated by demon blood. But as the apocalypse draws nearer, Bobby wants to free Sam to battle on their side.

Dean and Sam are killed by the hunters Walt and Roy. They awake in heaven and Castiel contacts Dean and asks him to seek out the angel Joshua. Meanwhile Zachariah is chasing them in Heaven to force Dean to be Michael's vessel.

Dean and Sam are captured by Meg who wants to know Crowley's hideout. Sam proposes to show where Crowley is provided she gets his soul back. The Winchester brothers ask the reluctant Samuel who has made a deal with Crowley to have his daughter Mary back but he finally points out the spot. Dean and Sam break into an old prison with Castiel, Meg and two other demons to seek out Crowley, but they are betrayed by Samuel. Castiel escapes, but Sam and Dean are arrested and Meg is tortured by Christian. Will that be the end of the quest of the Winchester brothers for Sam's soul?

Dean, Sam, Castiel and Bobby find Eve in a small town where the citizens have been converted to demons; Eve decides to torture Sam and Dean by bringing their mother back as a demon.

James Frampton, an old friend of Sam and Dean, has become a witch. Now he's supposedly killing innocent people.

Chuck tries to lock Amara away for good but then faces some unexpected complications.

Dean comes face to face with his mother while Sam fights for his life after being shot by Toni.

Dean, Castiel and Mary have a lead on Sam and set out to rescue him. Dean is uncomfortable putting Mary in danger, but she insists on going. Meanwhile, Crowley is tipped off that Lucifer has taken over the body of rock star Vince Vicente.

When a crying baby leads to death in a mysterious abandoned house, Mary, Sam and Dean decide to investigate. Meanwhile, Castiel's hunt for Lucifer leads him, begrudgingly, to partner up with Crowley.

When hunters gather together to celebrate the life and tragic death of one of their own, Sam, Dean and Mary must take action when a demon starts picking off hunters one by one.

Sam and Dean must find a way to escape from a government-run detention facility; in an effort to find her sons, Mary and Castiel seek assistance from a surprising source.

Mary asks Sam, Dean and Castiel for help on a case she's working, but neglects to mention the British Men of Letters are involved. When Mary is double crossed, everything is revealed.

A ghost from a merchant ship may be responsible for a murder at a museum; an angel tries to kill Kelly.

Mary and the British Men of Letters have a chance to take out a nest of Vampires, but the alpha-vamp turns the tables on them.

Sam and Dean get a lead on Kelly Kline's whereabouts. Mick drops by the bunker unexpectedly and decides to join the hunt.

Alicia Banes calls Mary for help after her mother goes missing. Later, Mary begins to have some doubts about the British Men of Letters.

Sam and Dean are alarmed when they learn hunters are being killed by suspicious "accidents" all over the country. They decide it is best to find Mary and make sure she's safe. Meanwhile, Toni is back in the states and she and Mary face off.

Sam and Dean only have each other to rely on when they're caught in a dangerous situation; the fight between the American hunters and the British hunters comes to a head.

Lucifer battles Sam, Dean and Castiel for control of his unborn son.

Sam and Dean are left to pick up the pieces following the loss of their mother, Crowley's demise and Castiel's death.

Sam and Dean discover what Jack is capable of with his powers.

Jack, desperate to prove to Sam and Dean that he is good and that he can control his powers, enlists the help of a dream walker named Kaia to help him find Mary Winchester and save her from the alternate universe. However, when plans go awry, the Winchester brothers are the ones who need saving.

Jack and Mary escape Michael's clutches and end up finding an ally in Bobby Singer; Sam, Dean, and Castiel continue to search for a way to open a breach; one of their own may be working against them and costing them precious time.

Gabriel is back and drags Dean and Sam into his plot for revenge on the demigods who sold him to Asmodeus. Meanwhile, Jack's growing confidence leads to reckless decisions that could put others in harm's way.

Sam, Dean, Castiel and Gabriel must work together if they have any hope of bringing Mary and Jack home. Meanwhile, Rowena's encounter with Lucifer may alter the outcome of the journey for one of our heroes.

Sam and Dean devise a plan that will save innocent lives. Meanwhile, Jack continues to wrestle with the consequences of his decisions.

Our heroes, Sam and Dean Winchester, continue to be tested in the battle between good and evil, but one impulsive decision could alter the lives of one of the brothers forever.

Sam enlists everyone's help in trying to track down Dean, who can literally be anywhere. Meanwhile, Castiel may be in over his head after meeting up with an unreliable source. After being drained of his grace, Jack is adjusting to life as a human, learning new skills and figuring out how he fits in to this world of hunters.

Sam finds a clue to Dean's whereabouts, so he, Mary and Bobby set out to investigate. Castiel imparts some sage advice on Jack, who, still desperate to belong, seeks out a familial connection.

After a hunt gone wrong leaves Maggie's whereabouts unknown, Sam, Dean, Mary and Bobby race to find her, but what they find are their own worst nightmares.

Dean spends some bonding time with Mary and Donna. Nick finally finds the answer he has been searching for. Sam is left to make an unimaginable choice.

Sam and Dean look to occult lore for a solution to their latest problem, but instead of a resolution, they find much more than either of them had anticipated.

Sam and Dean race to help a friend in need. Meanwhile, Mary is concerned for Jack's wellbeing, and Castiel enlists help from Jo/Anael to track down a miracle.

Sam and Dean continue to worry about the condition of Jack's soul.

Everything is on the line as the battle against God continues; a familiar face returns to join the fight.

Sam and Dean continue to worry about the condition of Jack's soul.

Dean, Castiel and Mary have a lead on Sam and set out to rescue him. Dean is uncomfortable putting Mary in danger, but she insists on going. Meanwhile, Crowley is tipped off that Lucifer has taken over the body of rock star Vince Vicente.

When a crying baby leads to death in a mysterious abandoned house, Mary, Sam and Dean decide to investigate. Meanwhile, Castiel's hunt for Lucifer leads him, begrudgingly, to partner up with Crowley.

Alicia Banes calls Mary for help after her mother goes missing. Later, Mary begins to have some doubts about the British Men of Letters.

Dean comes face to face with his mother while Sam fights for his life after being shot by Toni.

When hunters gather together to celebrate the life and tragic death of one of their own, Sam, Dean and Mary must take action when a demon starts picking off hunters one by one.

Sam and Dean race to help a friend in need. Meanwhile, Mary is concerned for Jack's wellbeing, and Castiel enlists help from Jo/Anael to track down a miracle.

Sam and Dean are alarmed when they learn hunters are being killed by suspicious "accidents" all over the country. They decide it is best to find Mary and make sure she's safe. Meanwhile, Toni is back in the states and she and Mary face off.

Sam and Dean must find a way to escape from a government-run detention facility; in an effort to find her sons, Mary and Castiel seek assistance from a surprising source.

Following visionary Sam's recent nightmare about the former Winchester home in Lawrence, Kansas, where the present dwellers, Jenny from Wichita and mother to two small kids, are suspiciously accident-prone, Dean reluctantly accepts to drive there. Dean and Sam reassure Jenny but follow up on the kids fear of a flaming creature in the closet. They consult Missouri Moseley, their father John's old medium friend, and together with the spirit of Mary Winchester, confront an evil poltergeist, but a second ghost intervenes and someone hides behind Missouri.