Now that Paul knows about Cathy's melanoma, he wants to help her in any way he can, including investigating alternate treatments. He is also still trying to get over the fact that he lost three months in trying to help her, three months in her probably shortened life. Cathy tries to explain to him why she didn't didn't tell him sooner. Paul, in dealing with the spouse of someone who died of cancer, begins to move closer to Cathy's way of thinking. Meanwhile, Rebecca tells Sean that she is moving to Minneapolis, but doesn't quite get the reaction she wanted. In a girls' bonding session, Marlene, Cathy and Rebecca go out for lunch to an unusual locale, an incident at which makes Cathy believe that Paul's thoughts about dealing with her illness aren't completely wrong. And Cathy learns about Marlene's Alzheimer's.

In an effort to be supportive of Cathy's decision and to find out more about it, Dr. Todd accompanies Cathy to Canada for her bee sting therapy. As open as he tries to be, Dr. Todd just can't get around how quackish the whole therapy seems. After the treatment, Cathy too believes that the "Bee Man" is a lunatic, but is glad she made the decision to take a chance. As their trip progresses, many revelations about Dr. Todd's professional and personal life become known to Cathy, which explains why he seems so protective about Cathy and why he wanted to come on this trip. Before she left Minneapolis, Cathy found out that Adam is seeing a girl named Mia, who, if she is indeed his girlfriend, would be his first. Cathy takes an extreme but nonetheless effective measure to ensure that things go well for Mia and Adam's possible relationship, despite the less than helpful advice he receives from his Uncle Sean. And an incident between Marlene, Adam, and Paul makes Marlene take decisive action.

Cathy finds that her experience with the great Dr. Atticus Sherman isn't anything like she thought it would be. In addition to not appreciating his bedside manner, not believing that he pays any attention to her file, or not believing that he sees her anything more than another nameless face in his office, Cathy learns he is conducting a clinical trial, about which she learns from another of his stage 4 patients, an extremely positive woman named Nadine, in which he has no space for her. Meanwhile, Cathy and Sean's relationship is still strained over the fact that she kept her illness a secret from him for so long. As such, he is functioning even less well than normal, which means that Cathy is replacing him in many of Rebecca's "baby partner" functions. Rebecca makes an unusual request of Cathy, and further tells Cathy of a decision that doesn't sit well with her. And Cathy's return to work, where everyone now knows of her illness, places both her and Adam in an uncomfortable position.

Cathy and Paul experience frustration in the bedroom. Cathy and Paul need to set patient/caregiver limits, and Rebecca is put off by Sean.

Paul still not having a job places a strain on his and Cathy's financial situation with mounting medical bills. Paul has to make a decision to wait for the perfect job, to do freelance work without insurance, or take any job that has insurance. He is hoping that a meeting with his old friend Jimmy will lead to the first of those three. Cathy makes a unilateral decision for some one time immediate cash. In the process of getting that money, Cathy ends up spending the day with Lee, that day which takes an unexpected turn for her. Meanwhile, Adam makes another decision on how best to relieve his sexual frustration since Mia still wants to take things slow. Adam's actions result in him needing to turn to someone to get him out of a jam. That someone ends up being Sean who offers his own form of a solution to the problem.

Although he still hates his job, Paul settles into life at the electronics store. He bonds with a fellow employee, a young Ukrainian immigrant named Mykail, who in turn bonds with one of his customers. While Paul still struggles with his job situation, that struggle which includes reporting to a barely of age weaselly assistant manager, Cathy aims for an extra job at the school with more pay as the girl's swim coach. She is able to convince the principal to give her the job at least temporarily until the principal can find or wants to find a more permanent coach. Cathy believes she is both well suited to the job, and something she needs in her life right now. The only aspect she doesn't like is dealing with "stage" parents, one in particular who thinks he can do the job better than her. Meanwhile, Adam brings something into the house that threatens both his relationship with Mia as well as Cathy's position as swim coach.

Cathy believes the two best Christmas presents she received this year are Sean returning home after missing for three weeks while he went to find himself following Rebecca's departure, and watching Lee die peacefully in front of her, which has now made her not afraid of death. Taking a play from Lee, Cathy decides to finish what Lee didn't and couldn't: run the Minneapolis New Year's Eve Marathon, despite she not having trained for it at all. Her new mantra is to use her body while she still can. But the race entries have closed already which means that she has to find a creative way to enter the race. Adam receives an offer of reconciliation of sorts from Mia, which may interfere with something he feels is more important in his life at this time. And Cathy finds out about Paul and the electronics store parting company and the reason why. As this affects their health insurance, Paul goes on his own mission to ensure they get from the insurance company what they deserve.