Rebecca and Sean both have less than traditional ways to deal with Rebecca's miscarriage. Partly because Sean decides to go off his meds so that he can feel the true pain associated with it, Sean and Rebecca's methods of mourning end up being somewhat incompatible. Something that Rebecca and Sean do in combination about the miscarriage directly affects Cathy. In addition, it also makes Cathy realize that she has been so busy dealing with the life part of her illness that she totally forgot about the death part, namely making arrangements for what will happen to her body post-mortem. Meanwhile, Adam has joined an on-line support group called Kids of Cancer. After several on-line discussions with fellow kid of cancer "Poppy K", he suggests they meet to which Poppy wholeheartedly agrees. Poppy ends up being nothing like Adam imagined, which may not be a totally bad thing. And even though Paul asked for a part of the cut Mykail gets from lifting and selling items from the store, he begins to feel more uncomfortable about it when he sees the extent of Mykail's thefts.

Following their Thanksgiving fallout, Cathy and Lee reconcile, with Cathy vowing to be honest with him about how things are progressing with her health. She sticks to that vow as her news is generally positive, while his continues to decline. But Lee tries to remain upbeat, focusing on living. As such, Cathy decides to help him with his bucket list in whatever way she can. Meanwhile, Adam decides to continue hanging out with Poppy, in part to understand the thing he noticed on her arm when they first met. Poppy's decision on the where to hang out catches Adam off guard: her high school reunion, where she wants to show her former classmates that she didn't turn out the loser as they probably expected. Adam tries to help her achieve that perception. And Sean continues to deal with Rebecca's miscarriage in his own way, especially now that Rebecca has left him to go home to Chicago.

Cathy, Paul and Adam are getting ready to head to Italy for the Christmas holidays using Paul's cut from the electronics store thefts. They still haven't found Sean, but they feel they need to focus on themselves as a family. They are also leaving behind Andrea who is in engaged bliss to Mykail, with who she will spend the holidays. Owen tells Paul about the imbalance in store inventory, which leads to a revelation from Mykail which could affect his relationship with Andrea. Adam spends time with Poppy before he leaves. But he also finds out some information about Poppy's reality, which ultimately makes him understand why she acts the way she does. And Dr. Sherman asks Cathy to be "show and tell" to one of his classes. She tries to make her reality and the students' reality a little closer together. And just before the Jamisons are ready to head to the airport, Cathy receives a telephone call from Lee, who has an important pre-Christmas request from her.