Cathy receives two minor pieces of bad news on her latest check up. The first is that none of the drugs' listed negative side effects have afflicted her, which to her means that the drugs aren't working. The second is that she has high blood pressure. Despite Cathy disregarding it upon Sean's suggestion, Cathy takes Lee's advice to visit an acupuncturist - his acupuncturist - to treat the high blood pressure. The acupuncturist has slightly better news: she immediately relaxed, which means a drop in blood pressure, when Lee entered the room. The acupuncturist attributes that relaxation to her and Lee being soul mates, which to Cathy can only mean in the spiritual but non-sexual sense seeing as to Lee's homosexual orientation. But those homo/heterosexual boundaries between Lee, Cathy and Paul are tested, as are Cathy's notions of what it means truly to be one's soul mate. Meanwhile, Mykail is anticipating his first date with Andrea and what he hopes will happen.

Following their Thanksgiving fallout, Cathy and Lee reconcile, with Cathy vowing to be honest with him about how things are progressing with her health. She sticks to that vow as her news is generally positive, while his continues to decline. But Lee tries to remain upbeat, focusing on living. As such, Cathy decides to help him with his bucket list in whatever way she can. Meanwhile, Adam decides to continue hanging out with Poppy, in part to understand the thing he noticed on her arm when they first met. Poppy's decision on the where to hang out catches Adam off guard: her high school reunion, where she wants to show her former classmates that she didn't turn out the loser as they probably expected. Adam tries to help her achieve that perception. And Sean continues to deal with Rebecca's miscarriage in his own way, especially now that Rebecca has left him to go home to Chicago.

With Paul (Oliver Platt) recovering from his near-fatal heart attack, and Andrea (Gabourey Sidibe) returning from her African adventure, Cathy (Laura Linney) creates an alter ego as she gets some good news about her chemotherapy trial.

Cathy plans a birthday party.