A North Korean pianist announces his intention to defect in the Oval Office. While the staff passionately debate his request they also fight to get the President's choice of Vice President nominated by a new and hostile Speaker of the House.

President Bartlet refuses to let Speaker of the House Haffley hold him hostage on the budget and allows the government to be shut down.

The president and staff are about to head for Brussels to sign an international free trade deal that Josh has just spent a lot of time and effort negotiating, to nearly everyone's satisfaction; at the 11th hour, the CEO of an IBM-like company tells Josh that the first effect of the new agreement, of which his company is a huge beneficiary, will be the immediate transfer of 17,000 programming jobs to India; the head of the communications workers' union, which is representing the affected programmers, brings one of the programmers to Josh's office, and they refuse to leave, leading Josh to question the underlying adverse effects of the trade deal. Throughout the episode, Ryan tries to make Josh care that he's completing his internship that day, while Donna pesters Josh to bring her on the Brussels trip in an effort to make her a more active player in west wing activities, eventually leading to a trade-off that will mean even bigger things for Donna in the long run.

The President finds himself at odds with Leo, and the entire country, on his position regarding retaliation for the bombing in Gaza.

Leo is found in the woods and rushed to the hospital; the staff struggle to hold the peace deal together without a Chief of Staff; the President neglects his duties out of loyalty and guilt towards Leo; Donna arrives back in the USA.

On the same day that an anti-gay-marriage amendment is attached to the federal budget, an Internet rumor surfaces that C.J. is a lesbian. Josh and Toby attempt to kill the amendment without forcing the President to publicly take a position on this unwinnable issue. Congressman Santos considers Josh's proposition that he run for President despite having told his wife that he's done with politics. Donna begins her new job while Josh struggles to cope with her difficult replacement. Abby and C.J. meet with the President's doctors to decide how to adapt his schedule to the increasingly debilitating effect of multiple sclerosis.

Senator Arnold Vinick easily wins the Republican nomination on the night of the New Jersey primary, but has difficulty picking a running mate. Choosing Reverend Don Butler would virtually guarantee him the presidency, but their differing views on abortion and religion would make it a political union rather than one based on shared ideology. The Democratic nomination is a toss-up between Santos and Russell; Hoynes is running a distant third. With no clear nominee going into the convention, the Democratic party risks appearing unsure about both Santos and Russell - a position that President Bartlet does not want the Republicans to be able to exploit.

With Santos gaining momentum, the Vinick campaign devises a strategy to catch them off-guard by focusing on immigration issues: by taking a pro-immigration stance, they force Santos to spend time courting the Latino vote. A powerful Christian group is nervous about supporting a Republican presidential candidate who is pro-choice, and demands a guarantee that Vinick only appoint pro-life judges. Vinick hopes that the strong religious credentials of his running mate Sullivan will be enough to satisfy the Christian base, but inevitably finds himself in a difficult situation.