Dante, Elias, and Jay and Silent Bob are enlisted by Randal after a heart attack to make a movie about the convenience store that started it all.

Eleven years after the events of the Clerks, Dante Hicks (Brian O'Halloran) opens the Quick Stop convenience store to find that it is on fire; Randal Graves (Jeff Anderson) had left the coffee pot on after closing the night before. As a result of the destruction of Quick Stop and the adjacent RST Video, Dante and Randal begin working at a Mooby the Golden Calf fast food restaurant along with Elias (Trevor Fehrman) and their manager List of View Askewniverse characters#Becky Scott (Rosario Dawson). A year later, Dante is planning to leave his minimum wage lifestyle in favor of a family life in Florida with his fiancée Emma Bunting (Jennifer Schwalbach Smith), whose father will provide them with a home and a business to run. This leaves Randal, who fears that with Dante moving to Florida would leave him without his best friend, bitterly disappointed. Jay and Silent Bob (Jason Mewes and Kevin Smith) have since followed Dante and Randal, and now loiter outside of Mooby's. Jay and Silent Bob no longer do drugs after they were arrested for possession and were sent to Drug rehabilitation, and become devout Christians following their release. However, the duo continue selling drugs.

After getting a restraining order from Randal Graves (''Clerks'') for Illegal drug trade outside the Quick Stop, Jay and Silent Bob find out from Brodie Bruce (''Mallrats'') that ''Bluntman and Chronic'', the comic book based on their likenesses, has been adapted into a film in production by Miramax Films. In response, the two visit Holden McNeil (''Chasing Amy''), the co-writer of ''Bluntman and Chronic'' and demand royalties from the film. However, Holden tells Jay and Silent Bob that he sold his part of the creative and publishing rights of the comic over to his former friend Banky Edwards. Upon learning of the film, as well as the negative reaction it has received so far on the internet, the two set out on a quest to Hollywood, to prevent the film from being made and tainting their image, or at the very least receive the money from the royalties owed to them.

As the name suggests, the cast of ''Degrassi: The Next Generation'' travels to Los Angeles, California as they attempt to live out their dreams. While Manny Santos (Degrassi: The Next Generation) continues to pursue her acting career, Paige Michalchuk manages to acquire a leading role in a Hollywood film directed by Jason Mewes about his high school story and the girl of his dreams, Trixie. The dramatic relationship between Craig Manning and Ellie Nash continues to intensify after years of turbulence. Meanwhile, List of Degrassi: The Next Generation bands#Janie & The Studs—the band composed of Peter Stone (Degrassi character), Danny Van Zandt, and Sav Bhandari—seems to be headed towards their big break.

While Sidney and her friends visit the Hollywood set of 'Stab 3', the third film based on the Woodsboro murders, another Ghostface killer rises to terrorize them.

Furious over losing the legal rights to their names used in the reboot of the old "Bluntman & Chronic Movie" they hated, Jay and Silent Bob travel across the USA in an attempt to prevent the film from ever seeing the light of day.