The grand opening of Chicago Med's emergency department is interrupted by victims of an elevated train crash, pushing the staff to their limits.

Ethan finds himself at odds with Natalie and Sharon as he treats a teenage mother who abandoned her newborn baby in an alley.

Connor is forced to confront his past when he takes on the case of a close family friend who's been impaled by glass shards.

In the aftermath of a movie theater shooting, the doctors work to treat the victims while Sharon tries to keep the press at bay.

As Doctors Rhodes and Zanetti race against the clock to save a fallen member of Firehouse 51, the case of a woman clinging to life is discovered to be similar to those of other patients.

Sharon is visited by the Department of Homeland Security regarding two airplane stowaways who are brought to the hospital with major injuries.

Sharon must decide whether to put her job on the line for a patient in need.

A Saudi prince arrives for a surgical procedure, while Dr. Manning returns from maternity leave and treats a teen with a long history of medical issues.

Dr. Halstead jeopardizes his career when he goes against a family's orders and revives a terminally ill cancer patient.

Doctors Rhodes and Downey set aside their differences to operate on a 9/11 hero with pulmonary fibrosis.

Doctors Rhodes and Choi disagree over a dying patient's request.

Nurse Lockwood is arrested for refusing to take blood from a suspected DUI patient without his consent.

Dr. Halstead (Nick Gehlfuss) and Sharon Goodwin (S. Epatha Merkerson) deal with a husband intent on harvesting his recently deceased wife's eggs, but soon discover some vital information that surprises everyone. Dr. Charles (Oliver Platt) is brought in by Dr. Choi (Brian Tee) to aid a patient who is trying to remove his own arm from his body because he feels like it doesn't belong. Nurse Sexton (Yaya DaCosta) befriends the father of a child who is rushed into the hospital after swallowing magnets - a situation that Dr. Rhodes (Colin Donnell) and Dr. Manning (Torrey DeVitto) are concerned could present dangerous complications. Meanwhile, Sarah Reese (Rachel DiPillo) finally learns about where she will do her residency, but has last-minute second thoughts.

Doctors Choi and Charles are left with a patient claiming his heart is pounding in his head, while Dr. Manning suspects that a young boy with a broken wrist has deeper problems.

Doctors Manning and Charles have a 16-year-old patient with abdominal pain who refuses to take drugs, while Dr. Halstead has a patient who turns out to be an old high school classmate.

Doctors Rhodes and Downey have a disagreement over a patient's emergency heart surgery.

April and Dr. Halstead treat an alcoholic homeless man with a broken leg.

Dr. Rhodes treats Dr. Downey while Dr. Halstead receives clarity from Goodwin.