While driving her convertible at high-speed in the highway, a woman is stopped by a patrolman. Catherine and Grissom arrive later to the highway where the woman was found with slit throat and slashed genitals in her car. They also find a camcorder with no tape on the floor. The entire team investigate the case and Warrick and Sara find documents in the car, showing that the victim is Wendy Garner and the car's registration and the driver's license in the name of Walter Clancy. When Dr. Robbins finds a prostate in the victim, the team learns that she was a transsexual, and soon concludes that Wendy and Walter were the same person. When Grissom and Brass investigate Wendy's fiancé Aaron Laner, they learn that he does not know that Wendy was a transsexual. The team also interview her fellow dancers and learn that Dr. Mercer is the responsible for most of the transsexuals' operation. However, the doctor tells Catherine and Warrick that he refused to operate Wendy since she wanted to jump steps of the procedure required by the law. Now they are looking for the surgeon that might have operated Wendy.

Langston investigates a homicide which is connected to the discovery of rare valuable chips from a legendary casino from the 1980s.