While investigating the disappearance of Margaret Shorey at a supermarket, Grissom and Catherine stumble upon a serial killer who claims to have killed five women in supermarkets located along the I-15. Sara and Warrick are given the case of the death of a man who, his brother claims, was killed by a burglar. Sara soon suspects that the brother is not telling the truth. Nick is specially requested to solve a case of harassment.

Greg has found a replacement in the DNA lab, Chandra Moore, and introduces her to the co-workers. Capt. Brass, Grissom and Greg, in his first case, investigate the death of an unidentified victim with a shot in the forehead in a shooting in the nightclub owned by Manny Brazil. He says that he does not know how the gun has passed through the metal detector. Catherine and Det. Louis Vartann investigate the murder of a woman covered in blood in a hotel room. The man, Carl Johnson, also covered in blood, tells to the detectives that he has never seen that woman before. Soon they learn that the victim is the stripper Nicole "Raven" Richards that drugged Carl to rob him. Warrick and Det. Chris Cavaliere investigate the death of Lance Frazer, a loser that died in the bathtub electrified by heat exchanger causing a short circuit in the motel. Soon Warrick learns that Lance hit a fifty-thousand-dollar jackpot on the previous night. Nick, Sara and Det. Travis investigate an "alien" buried in a shallow grave near the Area 51.

Catherine investigates the murder of a young mother who claimed God got her pregnant, while Grissom witnesses a very shady trial.

A half-naked woman is found half buried in the desert with a branding on her arm. She has no hair and is missing her right hand. The woman turns out to be Lady Heather's estranged daughter. The autopsy reveals that the woman was a victim of an experiment and starved to death. The team investigates the Betz Clinic where the deceased underwent a sleep therapy session for her insomnia.