A person takes House, Thirteen and others as hostages. He's seen several doctors but none have found what ails him. As they work towards finding a solution, Thirteen makes decisions which leads her to think about her own condition.

This is a hectic day in Cuddy's life from 5AM to 9PM. Giving an insurance company an ultimatum could bankrupt the hospital. She fires an employee for theft. Her child's sick. A patient won't pay for a reattached thumb.

It's election season, and in the midst of a tight campaign, an incumbent New Jersey senator's campaign manager falls ill with liver failure and temporary paralysis. Cuddy pushes House to add a female doctor to his team by hiring brilliant third-year medical student Martha Masters in Thirteen's absence. House and the team are wary of the young doctor's lack of experience and medical perspective, but are forced to give their new by-the-book teammate a chance to prove herself. After the campaigning senator makes a surprising announcement, House and the team look to the candidate to find clues about the patient's condition. Meanwhile, Foreman learns that Taub has a past connection to Masters, and in an effort to save his patient's life, House must make a critical decision that may compromise his relationship with Cuddy.

House entertains a school class on Career Day telling about his patient, a college student, who coughed up his lung. He spices up the story with quotes from movies. He later gets advice from 2 students outside principal's office.

A prosecutor in court thinks he has a heart attack. Is it an anxiety attack? He has an arsenal hidden from his wife in their home. Taub tries to fix Foreman up with a nurse.

A man with Alzheimer's is offered a trial treatment after which he pukes blood. He ends with House and co. His wife claims to have an asexual marriage. House doesn't believe in asexual and bets Wilson.