Victor is co-counsel in defending a woman accused, along with her husband, of murdering their intellectually disabled newborn baby and who claim it was the result of Sudden Infant Death Syndrome. Meanwhile, Markowitz is arrested for drunk driving while on his way to a lunchtime tryst with Kelsey. At McKenzie's suggestion, Brackman starts seeing a sex therapist, named Marilyn Hopkins, to revise his non-existent sex life.

Victor is moved by a mother's pleas and agrees to make an emotional appeal for clemency for Hector Rodriguez, a old friend on death row facing execution. Meanwhile, Grace tackles her first case for the firm in defending an elderly man for the mercy killing of his wife who was dying from Alzheimer's Disease. Kelsey represents a frustrated Chicago Bears fan who is suing the team's staff. Kuzak's plans to leave the firm suddenly change when his father decides to come live his last days in Los Angeles. Also, Becker worries about his past life and about his mother's advice as he prepares to marry Corrinne.

Rosalind Shays returns with an equally ruthless and manipulative lawyer, Jack Sollers, to sue the firm for sexual discrimination. Markowitz suffers a heart attack during the trial and is put on leave. Meanwhile, Kuzak faces Darron Holloway, an angry, civil-rights black activist inciting the press and the public while he takes the case of defending Brian Chisolm, a white policeman accused of shooting a black youth. Also, Roxanne has more problems with her father, Murray, when she tells him that he has Alzheimer's Disease.

Kelsey and Sollers represent Suzanne Hamil, an obsessive woman charged with murdering her married lover, in which both her and Sollers resort to drastic measures to get their client acquitted by placing suspicion on the widow. Meanwhile, C.J. tries to defend a retiree accused of licking his Cane toad to get high. Also, McKenzie becomes a part-time arbitration judge to rule on a blues singer's lawsuit against his manager.

Kelsey faces disbarment for revealing knowledge of her former client Suzanne Hamil's murder obtained through attorney-client privilege. Victor, now an independent lawyer, is representing his old friend Mark Gilliam, an AIDS-stricken lawyer, suing an insurer for not providing coverage for his medical needs, while he and Grace finally marry. Meanwhile, Becker tells Roxanne that he has feelings for her and they end up falling through the ceiling while engaged in a little romp. Abby is finally made a partner, and McKenzie inherits Rosalind Shays' estate.

Since the departure of Michael Kuzak, Victor Sifuentes, Abby Perkins, and Jack Sollers from the firm, McKenzie and Brackman are looking for more litigator power. Grace, having suffered from a miscarriage and leaving Victor, returns to the firm and is immediately given a high-profile case with Mullaney in defending Elsa Chandler, a woman charged with murdering her abusive husband. McKenzie tries to adjust himself to the brash new tenant sharing office space, the crude, smart-mouthed, chain-smoking, entertainment lawyer Susan Bloom, to boost revenues for the sagging firm. Meanwhile, Becker's secretary, Gwen Taylor, is on jury duty and witnesses Bloom's associate, the crafty Frank Kittredge, go to the limits of ethics to defend his wealthy client from an assault charge. Kelsey and Markowitz struggle to find the right nanny for their son, Matthew, and they hire Ned Barron, a college student just right for the job. Also, Billy Castroverti is hired as a new junior associate.