Detective Murdoch, Inspector Brackenreid, Dr. Ogden and several others are transporting serial killer James Gillies to the prison in Kingston, Ontario where he is scheduled to be executed the next day. It creates a bit of a stir among the passengers when they learn who is being transported. Among them are Aaron Rauls, a late arrival on the train and Nathaniel Henry. Both come under suspicion when the police find a dead man, Dennis Bolton who was released from the Don jail just a week ago. There's no direct connection between Bolton and Gillies but both were in the same jail at the same time. As tensions rise, it becomes evident that Gillies has arranged for several ex-convicts to be on the train - all part of his plan to escape.

A horrific murder at the public introduction of the Murdochs' new residence designed by Frank Lloyd Wright puts the couple on the case.