Revolves around an unattractive secretary at a fashion magazine. Based on the Colombian telenovela "Betty La Fea."

Ignacio Suarez is in a desperate situation as his secrets can't stay disclosed. Wilhelmina offers financial help but Betty is hesitating whether to accept it. Daniel meets a fascinating woman in the elevator. He's totally unaware that she's about to get a leading role in the company. Wilhelmina's daughter, Nico, fights to attract her mother's attention.

Sofia Reyes spreads herself in Daniel's office to prove her power. But, instead of paying attention to him Sofia is interested in Betty's opinions and ideas. Fearing that his assistant is not challenged enough by her job, Daniel sends Betty off to write a review about a hotel where she is supposed to stay at over the weekend. Actually, Betty has planned to spend the weekend with Walter in Atlantic City, but now has to cancel this trip. When, Walter pays her a surprise visit at the hotel, Betty is at first very relieved to see him. But, when Betty continues her review observations of the hotel, Walter is not very helpful. Meanwhile, at MODE, Daniel, who is still interested in Sofia, continues to try to get her attention, but Sofia seems to be very resistant to his charms. And, Wilhelmina has a meeting with an important client, but has to dress up for this meeting in very unusual clothes for her and as it turns out she has to do much more to please him.. At home, Hilda still tries to get the money together the family needs for a lawyer. Being very desperate, she asks Santos, who gives her the money, but in exchange wants to see his and Hilda's son Justin.

To his dismay, Daniel must attend his family's Thanksgiving gathering at the Country Club. Meanwhile, Amanda and Marc create their own gathering at Mode and there is also a dinner at Betty's house where Santos, Justin's father, is in attendance. Meanwhile, Wilhelmina also hosts a Thanksgiving dinner as well but her feast doesn't look as good as it does in magazine pictures.

The day after Thanksgiving is no holiday for Betty, who struggles to pull together a last-minute Mode photo shoot with a famous couple and their baby. Meanwhile, Daniel suffers from the after effects of drinking whilst getting over Sofia and ends up spending the holiday with Betty's family and Wilhemina and Marc get 'lost' in Queens!

It's Christmas at Mode as Betty questions her relationship with Walter and her feelings for Henry the accountant. Daniel, on the other hand, is sure of his love for Sofia.

Sophia Reyes rules Daniel Meade's heart masterfully, getting him to propose to her and winning favor with his parents. Meanwhile as Betty's new boss, Sophia orders her to replace a lead article in her new feminist magazine by one on the social experiences of her, common ugly bird, working in Daniel's fancy fashion magazine, so she goes back there interviewing everybody. Betty finds out that Sophia not only continues to enjoy the services of Hunter, who is actually exotic dancer, but also hired him to play her fiance. Betty deduces Sophia seduced Daniel maliciously, but is too late to tell him before Sophia announces on national TV she only wanted to prove the validity of her book's 60 days plan to hook up any man. She turns his proposal down, which totally destroys his spirit. Meanhile Texan lover Ted LeBeau renders Wilhelmina romantic enough to turn a cold shoulder to her shady boss, until his wife wants him back as father of their children. Betty's dad Ignacio finds he can't get out of the demands of mean Immigration official Constance Grady, who will get him deported even after 30 years of total integration unless he satisfies her.

Wilhelmina, with Mark as her right hand, plans who's to stay and who'll be kicked out when she once takes over Daniel's position. Daniel returns to the office after 14 days licking wounds. He immediately rehires Betty as assistant. Hilda has success in delivering her father's cakes and chooses to start a new business without telling him about it before taking in orders.