A young successful marketing executive goes missing. Although her life seems full of happiness and achievement on the outside, the team learns she is actually living a sad and lonely life full of drugs, family issues, and failed relationships. Martin has a serious lapse in judgment on his first day on the job.

Mr. Freedman gave his doted son Gabe a ticket to meet in the baseball stadium as an eleventh birthday present, but the knave never arrived. The model pupil was atypically distracted, and sold the ticket with profit to a scalper, joined a dubious gang and got into unprecedented trouble raiding a shop where the owner got badly hurt. After Martin Fitzgerald's brilliant work sifting tips from the mostly useless public to help work out Gabe wasn't abducted or running away but going somewhere, actually in search of his biological father, having found out he's adopted, Martin is finally taken along on field mission. Gabe took off to Texas to his 'dad', but the real one, which his parents didn't even know, died years ago, so it's probably a pedophile trap.

The mayor of a New York state countryside small town where people lock cars nor houses had to call the FBI for the disappearance of a teenage school girl last seen at the school bus stop. While the team learns about the close community, the victim's confident friend also goes missing. The MO fits similar cases in other inconspicuous places roughly on a line, so it's feared the work of a traveling serial pedophile.

Audrey Rose-Beckworth disappears on her wedding day. Evidence suggests that she has been abducted, but the team uncover a past tainted with drug abuse, and a one night stand prior to her wedding day. Somehow, everything relates to the groom's family, which whom she has a close connection, but the secrets run deep and family members are reluctant to reveal them.

Jack's squad must determine the best course of action when Samantha is shot and possibly critically injured in a hostage situation. After the ransom drop for a woman who has disappeared goes dreadfully wrong, Samantha becomes trapped in a bookstore by the kidnapper, Barry Mashburn, who has discovered that she is an FBI agent.

A bus full of students goes missing during the middle of its morning round. It becomes clear that the bus was hijacked. When it is finally located, it is empty save for one student who explains that the hijackers were two of his classmates who want a large ransom.

A talented and famous teenage violin performer, a Russian immigrant, goes missing. The team suspects her family, boyfriend or an apparently creepy fan.

A suburban mother goes missing in broad daylight, similar to another case from years ago where Jack failed to save the victim. Graham Spalding copycats the case only to taunt Jack and seek revenge.

A self-help guru is reported missing, but the team learns that he is not who he claims to be, and that he may have staged his own kidnapping as a publicity stunt.

The FBI investigates the disappearance of Eric Miller, a middle school student who disappeared during a bathroom break. He was only away for about ten minutes, so either he or his suspected kidnappers may have known what would happen. The investigators learn that Eric had low self-esteem and saw himself as part of the loser crowd at school. When his friend tells Agent Johnson about a bullying incident and they also locate a surveillance video from a local arcade showing an older boy pushing him, they realize they may have something other than a kidnapping.

For four years Vivian refused to give up on a dead-end case of a struggling sex addict who went missing. Her perseverance pays off when she receives a break in the case. The hunt for the young woman leads the team on a trail of addiction, abuse, and a strange cult.

The team investigates the disappearance of a wealthy family's newborn child and their nanny who was recently fired for stealing.

Jack and the team search for Peter Dusek, a wealthy, 72-year-old murder trial juror, whose disappearance could cause a mistrial. Although the agents initially suspect that the defendant may have orchestrated Peter's disappearance as a means of forcing a mistrial, they soon wonder if the juror disappeared of his own volition, since he tried to recuse himself with a note from his cardiologist the day after the defendant threatened a witness in the courtroom.

Jack and the team investigate the disappearance of Chelsea Prince, a 23-year-old society girl known for her constant partying and headline-grabbing escapades. Her badly beaten limousine driver recounts how the limo was ambushed and Chelsea was taken.

The team helps Danny search for his missing, estranged brother, Rafael "Rafi" Alvarez (ALEX FERNANDEZ), a recovering drug addict and ex-convict who Danny grimly suspects may have lapsed into his illegal and destructive past habits.

During an ambush, a hail of gunfire seriously wounds Martin and kills the FBI detainee that he and Danny were transporting.

A Sudanese boy adopted by a high-profile New York couple disappears, and it is connected to a Sudanese man trying to extort the couple, claiming that he is the child's biological father.

A television reporter's disappearance is tied to her son's torture and death in a Guatemala prison. Jack is forced to bring in the CIA to help crack the case.

A young woman disappears after her boyfriend is killed in a police shooting. Agents believe the disappearance is connected to the girl's brother, a notorious gang leader who had a falling-out with her.

A college student disappears after his racist statements are posted on an Internet video site, but the case reveals a secret about the student's racial identity and his real father.

The disappearance of a private investigator is connected to a foster child in his building that he was trying to help.